Transcription termination by nuclear RNA polymerases

被引：248

作者：

Richard, Patricia ^{[1
]}

Manley, James L. ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 11期

关键词：

Transcription termination; RNA polymerase I; RNA polymerase II; RNA polymerase III; yeast; mammals; PRE-MESSENGER-RNA; SMALL NUCLEOLAR RNAS; 3' END FORMATION; POLYADENYLATION FACTOR CPSF-73; CRYPTIC UNSTABLE TRANSCRIPTS; POLY(A) SITE RECOGNITION; BINDING PROTEINS NRD1; II ELONGATION COMPLEX; SR-LIKE PROTEIN; HUMAN U2 SNRNA;

D O I：

10.1101/gad.1792809

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gene transcription in the cell nucleus is a complex and highly regulated process. Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs its own mechanisms for initiation, elongation, and termination. Termination mechanisms vary considerably, ranging from relatively simple to exceptionally complex. In this review, we describe the present state of knowledge on how each of the three RNA polymerases terminates and how mechanisms are conserved, or vary, from yeast to human.

引用

页码：1247 / 1269

页数：23

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