The transcription factor ATF-3 promotes neurite outgrowth

被引：180

作者：

Seijffers, Rhona

Allchorne, Andrew J.

Woolf, Clifford J. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Neural Plast Res Grp, Dept Anesthesia & Crit Care, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2006年 / 32卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.mcn.2006.03.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dorsal root ganglion (DRG) neurons regenerate after a peripheral nerve injury but not after injury to their axons in the spinal cord. A key question is which transcription factors drive the changes in gene expression that increase the intrinsic growth state of peripherally injured sensory neurons? A prime candidate is activating transcription factor-3 (ATF-3), a transcription factor that we find is induced in all DRG neurons after peripheral, but not central axonal injury. Moreover, we show in adult DRG neurons that a preconditioning peripheral, but not central axonal injury, increases their growth, correlating closely with the pattern of ATF-3 induction. Using viral vectors, we delivered ATF-3 to cultured adult DRG neurons and find that ATF-3 enhances neurite outgrowth. Furthermore, ATF-3 promotes long sparsely branched neurites. ATF-3 overexpression did not increase c-Jun expression. ATF-3 may contribute, therefore, to neurite outgrowth by orchestrating the gene expression responses in injured neurons. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：143 / 154

页数：12

共 86 条

[1] OVEREXPRESSION OF THE NEURAL GROWTH-ASSOCIATED PROTEIN GAP-43 INDUCES NERVE SPROUTING IN THE ADULT NERVOUS-SYSTEM OF TRANSGENIC MICE [J].