The effects of chronic alcohol abuse on pulmonary glutathione homeostasis

被引:167
作者
Moss, M
Guidot, DM
Wong-Lambertina, M
Ten Hoor, T
Perez, RL
Brown, LAS
机构
[1] Emory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
[2] Emory Univ, Sch Med, Dept Med, Div Pulm & Crit Care, Atlanta, GA USA
[3] Carlyle Fraser Heart Ctr, Atlanta, GA USA
[4] Emory Univ, Dept Pediat, Div Neonatol, Atlanta, GA 30322 USA
[5] Atlanta Vet Adm Med Ctr, Decatur, GA USA
关键词
D O I
10.1164/ajrccm.161.2.9905002
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The incidence and severity of the acute respiratory distress syndrome (ARDS) is increased in critically ill patients with a prior history of chronic alcohol abuse; however, the specific mechanisms responsible for this association are unknown. Recently, we determined that chronic ethanol ingestion in rats decreased the alveolar epithelial lining fluid (ELF) concentration of the antioxidant glutathione (GSH), which is a characteristic finding in patients with ARDS, However, the effects of chronic alcohol abuse on the human alveolar epithelium are essentially unknown. Therefore, as a first step we asked if chronic alcohol abuse, independent of other comorbid conditions, decreases the concentration of GSH in the human lung. We determined that otherwise healthy chronic alcoholics had significantly decreased ELF concentrations of GSH compared with nonalcoholic control subjects (79 mu mol [48 to 118 mu mol] versus 576 mu mol [493 to 728 mmol], p < 0.001). Furthermore, the percentage of GSH in the oxidized form was higher in the chronic alcoholics (9.8% [2.2 to 14.8%] versus 2.8% [0.4 to 4.0%] p = 0.05), indicative of increased utilization of GSH. This is the first; report that chronic alcohol abuse alters GSH homeostasis in the human lung, and suggests a potential mechanism by which chronic alcohol abuse predisposes susceptible patients to develop ARDS.
引用
收藏
页码:414 / 419
页数:6
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