Advances in Management of Neuropsychiatric Syndromes in Neurodegenerative Diseases

被引：44

作者：

Cummings, Jeffrey ^{[1
,2
]}

Ritter, Aaron ^{[2
]}

Rothenberg, Kasia ^{[3
]}

机构：

[1] UNLV, Sch Integrated Hlth Sci, Dept Brain Hlth, 4505 S Maryland Pkwy, Las Vegas, NV 89154 USA

[2] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, 888 W Bonneville Ave, Las Vegas, NV 89106 USA

[3] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Cleveland, OH 44106 USA

来源：

CURRENT PSYCHIATRY REPORTS | 2019年 / 21卷 / 08期

关键词：

Neurodegenerative disorders; Neuropsychiatric syndromes; Alzheimer's disease; Parkinson's disease; Depression; Psychosis; Apathy; Agitation; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS ASSOCIATION WORKGROUPS; PLACEBO-CONTROLLED TRIAL; NURSING-HOME RESIDENTS; A-DOUBLE-BLIND; PARKINSONS-DISEASE; DIAGNOSTIC-CRITERIA; PSYCHOLOGICAL SYMPTOMS; ATYPICAL ANTIPSYCHOTICS; BEHAVIORAL DISTURBANCES;

D O I：

10.1007/s11920-019-1058-4

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Purpose of Review Neuropsychiatric syndromes (NPS) are common in neurodegenerative disorders (NDD). This review describes the role of NPS in the diagnosis of NDD, criteria for the diagnosis of NPS, management of NPS, and agents in clinical trials for NPS. Recent Findings NPS play an increasingly important role in the diagnosis of NDD. Consensus diagnostic criteria have evolved for psychosis, depression, agitation, and apathy in NDD. With one exception-pimavanserin is approved for the treatment of hallucinations and delusions in Parkinson's disease-there are no drugs approved by the FDA for treatment of NPS in NDD. Trials show that atypical antipsychotics reduce psychosis in AD and in Parkinson's disease, although side effect concerns have constrained their use. Antidepressants show benefit in treatment of Parkinson's disease with depression. Several agents are in clinical trials for treatment of NPS in NDD. Neuropsychiatric syndromes play a major role in NDD diagnosis. Clinical criteria allow recognition of NPS in NDD. Psychotropic medications are often useful in the treatment of NPS in NDD; efficacious, safe, and approved agents are needed.

引用

页数：14

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