Involvement of Epigenetic Mechanisms and Non-coding RNAs in Blood-Brain Barrier and Neurovascular Unit Injury and Recovery After Stroke

被引:53
作者
Stamatovic, Svetlana M. [1 ]
Phillips, Chelsea M. [2 ]
Martinez-Revollar, Gabriela [1 ]
Keep, Richard F. [3 ,4 ]
Andjelkovic, Anuska, V [1 ,3 ]
机构
[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Neurosci Grad Program, Ann Arbor, MI USA
[3] Univ Michigan, Sch Med, Dept Neurosurg, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Sch Med, Dept Mol Integrat Physiol, Ann Arbor, MI USA
关键词
blood brain barrier; neurovascular unit; stroke injury; inflammation; DNA methylation; histone deacetylases; microRNA; non-coding RNA; HISTONE ARGININE METHYLATION; ISCHEMIA-REPERFUSION INJURY; OXYGEN-GLUCOSE DEPRIVATION; FOCAL CEREBRAL-ISCHEMIA; FUNCTIONAL RECOVERY; GENE-EXPRESSION; AQUAPORIN; RAT-BRAIN; INFLAMMATORY RESPONSE; CHROMATIN STRUCTURE;
D O I
10.3389/fnins.2019.00864
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Cessation of blood flow leads to a complex cascade of pathophysiological events at the blood-vascular-parenchymal interface which evolves over time and space, and results in damage to neural cells and edema formation. Cerebral ischemic injury evokes a profound and deleterious upregulation in inflammation and triggers multiple cell death pathways, but it also induces a series of the events associated with regenerative responses, including vascular remodeling, angiogenesis, and neurogenesis. Emerging evidence suggests that epigenetic reprograming could play a pivotal role in ongoing post-stroke neurovascular unit (NVU) changes and recovery. This review summarizes current knowledge about post-stroke recovery processes at the NVU, as well as epigenetic mechanisms and modifiers (e.g., DNA methylation, histone modifying enzymes and microRNAs) associated with stroke injury, and NVU repair. It also discusses novel drug targets and therapeutic strategies for enhancing post-stroke recovery.
引用
收藏
页数:15
相关论文
共 176 条
[1]
Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity [J].
Aapola, U ;
Liiv, I ;
Peterson, P .
NUCLEIC ACIDS RESEARCH, 2002, 30 (16) :3602-3608
[2]
Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke [J].
Alfieri, Alessio ;
Srivastava, Sail ;
Siow, Richard C. M. ;
Cash, Diana ;
Modo, Michel ;
Duchen, Michael R. ;
Fraser, Paul A. ;
Williams, Steven C. R. ;
Mann, Giovanni E. .
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 65 :1012-1022
[3]
Long non-coding RNAs and cell death following ischemic stroke [J].
Alishahi, Masoumeh ;
Ghaedrahmati, Farhoodeh ;
Kolagar, Tannaz Akbari ;
Winlow, William ;
Nikkar, Negin ;
Farzaneh, Maryam ;
Khoshnam, Seyed Esmaeil .
METABOLIC BRAIN DISEASE, 2019, 34 (05) :1243-1251
[4]
Sequence-specific MR Imaging Findings That Are Useful in Dating Ischemic Stroke [J].
Allen, Laura M. ;
Hasso, Anton N. ;
Handwerker, Jason ;
Farid, Hamed .
RADIOGRAPHICS, 2012, 32 (05) :1285-1297
[5]
microRNAs: Tiny regulators with great potential [J].
Ambros, V .
CELL, 2001, 107 (07) :823-826
[6]
Regulation of CXCR4 gene expression in breast cancer cells under diverse stress conditions [J].
Andreou, Kleopatra ;
Rajendran, Ramkumar ;
Krstic-Demonacos, Marija ;
Demonacos, Constantinos .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 41 (06) :2253-2259
[7]
Protection after stroke: cellular effectors of neurovascular unit integrity [J].
Andres Posada-Duque, Rafael ;
Barreto, George E. ;
Patricia Cardona-Gomez, Gloria .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2014, 8
[8]
Ischemic Heart Disease and Stroke in Relation to Blood DNA Methylation [J].
Baccarelli, Andrea ;
Wright, Robert ;
Bollati, Valentina ;
Litonjua, Augusto ;
Zanobetti, Antonella ;
Tarantini, Letizia ;
Sparrow, David ;
Vokonas, Pantel ;
Schwartz, Joel .
EPIDEMIOLOGY, 2010, 21 (06) :819-828
[9]
Expression of Histone Deacetylases in Cellular Compartments of the Mouse Brain and the Effects of Ischemia [J].
Baltan, Selva ;
Bachleda, Amelia ;
Morrison, Richard S. ;
Murphy, Sean P. .
TRANSLATIONAL STROKE RESEARCH, 2011, 2 (03) :411-423
[10]
Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement [J].
Bauer, Alexander T. ;
Buergers, Heinrich F. ;
Rabie, Tamer ;
Marti, Hugo H. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2010, 30 (04) :837-848