Novel synthetic routes to PNA monomers and PNA-DNA linker molecules

被引：51

作者：

Breipohl, G

Will, DW

Peyman, A

Uhlmann, E

机构：

[1] Hoechst Marion Roussel D.

来源：

TETRAHEDRON | 1997年 / 53卷 / 43期

关键词：

D O I：

10.1016/S0040-4020(97)01044-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel methods for the preparation of monomethoxytrityl (Mmt) protected aminoethylglycine building blocks and dimethoxytrityl (Dmt) protected hydroxyethylglycine derivatives useful for the synthesis of polyamide nucleic acids (PNAs) and PNA/DNA chimeras are described. The protecting group strategy employed for PNA monomer synthesis produces easily isolable intermediates, minimizes chromatographic purification, and is suitable for large-scale monomer synthesis. (C) 1997 Elsevier Science Ltd.

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页码：14671 / 14686

页数：16

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