Formal Synthesis of (±)-Roseophilin

被引：60

作者：

Bitar, Abdallah Y. ^{[1
]}

Frontier, Alison J. ^{[1
]}

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 01期

关键词：

PRODIGIOSIN ALKALOIDS; NAZAROV CYCLIZATION; TRICYCLIC CORE; ROSEOPHILIN; CHEMISTRY;

D O I：

10.1021/ol802329y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A formal synthesis of (+/-)-roseophilin is described. Scandium(III)-catalyzed Nazarov cyclization of 2,5-disubstituted N-tosylpyrrole 19 gives a 5,5'-fused ketopyrrole, and ansa-bridge formation via pi-allyl palladium macrocyclization gives 21.

引用

页码：49 / 52

页数：4

共 35 条

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