Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels

被引：45

作者：

Camargo, Antonio ^{[1
,2
]}

Alberto Rangel-Zuniga, Oriol ^{[1
,2
]}

Haro, Carmen ^{[1
,2
]}

Romina Meza-Miranda, Eliana ^{[1
,2
]}

Pena-Orihuela, Patricia ^{[1
,2
]}

Eugenia Meneses, Maria ^{[1
,2
]}

Marin, Carmen ^{[1
,2
]}

Maria Yubero-Serrano, Elena ^{[1
,2
]}

Perez-Martinez, Pablo ^{[1
,2
]}

Delgado-Lista, Javier ^{[1
,2
]}

Manuel Fernandez-Real, Jose ^{[2
,3
]}

Luque de Castro, M. Dolores ^{[4
]}

Jose Tinahones, Francisco ^{[2
,5
]}

Lopez-Miranda, Jose ^{[1
,2
]}

Perez-Jimenez, Francisco ^{[1
,2
]}

机构：

[1] Univ Cordoba, Reina Sofia Univ Hosp, Lipids & Atherosclerosis Unit, IMIBIC, E-14004 Cordoba, Spain

[2] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain

[3] Inst Invest Biomed Girona IDIBGI, Dept Diabet Endocrinol & Nutr, Girona, Spain

[4] Univ Cordoba, Reina Sofia Univ Hosp, Dept Analyt Chem, IMIBIC, E-14004 Cordoba, Spain

[5] Hosp Virgen Victoria, Endocrinol & Nutr Serv, Malaga, Spain

来源：

FOOD CHEMISTRY | 2014年 / 162卷

关键词：

Virgin olive oil; Phenolic compounds; Inflammation; Transcription factor; Toll-like receptor; Lipopolysaccharides; NF-KAPPA-B; MEDITERRANEAN-STYLE DIET; BLOOD MONONUCLEAR-CELLS; METABOLIC SYNDROME; SYSTEMIC INFLAMMATION; ADIPOSE-TISSUE; RISK-FACTORS; HUMAN HEALTH; POLYPHENOLS; ACTIVATION;

D O I：

10.1016/j.foodchem.2014.04.047

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

We investigated the molecular mechanisms by which phenolic compounds (phenols) in virgin olive oil reduce the postprandial inflammatory response with the aim of identifying the transcription factor involved and the downstream effects. Olive oil-based breakfasts prepared with virgin olive oil (VOO) with high (398 ppm), intermediate (149 ppm) and low (70 ppm) phenol content were administered to 49 metabolic syndrome patients following a randomized crossover design. The consumption of a high-phenol VOO-based breakfast limited the increase of lipopolysaccharide plasma levels, TLR4, and SOCS3 proteins (p <0.001, p = 0.041 and p = 0.008, respectively), the activation of NF-kappa B (p = 0.016) and the IL6 (p = 0.007 and p = 0.048, low and intermediate oil, respectively), IL1B (p = 0.002, intermediate oil), and CXCL1 (p = 0.001) postprandial gene expression, in peripheral blood mononuclear cells, as compared with the consumption of a breakfast prepared with the same oil but with low or intermediate phenol content. Virgin olive oil phenolic compounds reduce the postprandial inflammatory response in association with postprandial plasma lipopolysaccharide levels. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：161 / 171

页数：11

共 73 条

[1]

ALLAIN CC, 1974, CLIN CHEM, V20, P470

[2]

Phytochemistry - Ibuprofen-like activity in extra-virgin olive oil [J].