The kinetic-segregation model: TCR triggering and beyond

被引：419

作者：

Davis, Simon J. ^{[1
]}

van der Merwe, P. Anton

机构：

[1] Univ Oxford, Nuffield Dept Clin Med, Oxford, England

[2] John Radcliffe Hosp, Weatherall Inst Mol Med, MRC, Human Immunol Unit, Oxford OX3 9DU, England

[3] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/ni1369

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

How the T cell receptor engages antigen is known, but not how that 'triggers' intracellular signaling. The first direct support for a mechanism based on the spatial reorganization of signaling proteins, proposed 10 years ago and referred to as the 'kinetic-segregation' model, is now beginning to emerge, along with indications that it may also apply to the triggering of nonclonotypic receptors. We describe here the development of the model, review new data and suggest how the model fits a broader conceptual framework for receptor triggering. We also consider the capacity of the model, versus that of other proposals, to account for the established features of TCR triggering.

引用

页码：803 / 809

页数：7

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