No synergistic effect between -850 tumor necrosis factor-α promoter polymorphism and apolipoprotein E ε4 allele in Alzheimer's disease

被引：19

作者：

Infante, J

Llorca, J

Berciano, J

Combarros, O ^{[1
]}

机构：

[1] Univ Cantabria, Hosp Marques Valdecilla, Serv Neurol, Santander 39008, Spain

[2] Univ Cantabria, Sch Med, Div Prevent Med, Santander 39008, Spain

来源：

NEUROSCIENCE LETTERS | 2002年 / 328卷 / 01期

关键词：

Alzheimer's disease; tumor necrosis factor-alpha; apolipoprotein E; gene polymorphism;

D O I：

10.1016/S0304-3940(02)00453-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the brains of Alzheimer's disease (AD) patients, microglia cells are activated and produce inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha). A recent study conducted in Northern Ireland showed that a polymorphism in the promotor region (-850) of the TNF-a gene increased the risk of AD associated with carriage of the apolipoprotein E (APOE) epsilon4 allele. In a case-control study restricted to a population from Northern Spain and utilizing 321 sporadic AD patients and 312 control subjects, we have found that the -850 TNF-alpha polymorphism does not interact with the APOE gene to increase the risk associated with the epsilon4 allele. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：71 / 73

页数：3

共 11 条

[1] Inflammation and Alzheimer's disease [J].

Akiyama, H ;

Barger, S ;

Barnum, S ;

Bradt, B ;

Bauer, J ;

Cole, GM ;

Cooper, NR ;

Eikelenboom, P ;

Emmerling, M ;

Fiebich, BL ;

Finch, CE ;

Frautschy, S ;

Griffin, WST ;

Hampel, H ;

Hull, M ;

Landreth, G ;

Lue, LF ;

Mrak, R ;

Mackenzie, IR ;

McGeer, PL ;

O'Banion, MK ;

Pachter, J ;

Pasinetti, G ;

Plata-Salaman, C ;

Rogers, J ;

Rydel, R ;

Shen, Y ;

Streit, W ;

Strohmeyer, R ;

Tooyoma, I ;

Van Muiswinkel, FL ;

Veerhuis, R ;

Walker, D ;

Webster, S ;

Wegrzyniak, B ;

Wenk, G ;

Wyss-Coray, T .

NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421

[2] Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists - The Cache County Study [J].

Anthony, JC ;

Breitner, JCS ;

Zandi, PP ;

Meyer, MR ;

Jurasova, I ;

Norton, MC ;

Stone, SV .

NEUROLOGY, 2000, 54 (11) :2066-2071

[3]

Collins JS, 2000, AM J MED GENET, V96, P823, DOI 10.1002/1096-8628(20001204)96:6<823::AID-AJMG26>3.0.CO

[4]

2-I

[5] Association of an interleukin 1α polymorphism with Alzheimer's disease [J].

Du, Y ;

Dodel, RC ;

Eastwood, BJ ;

Bales, KR ;

Gao, F ;

Lohmüller, F ;

Müller, U ;

Kurz, A ;

Zimmer, R ;

Evans, RM ;

Hake, A ;

Gasser, T ;

Oertel, WH ;

Griffin, WST ;

Paul, SM ;

Farlow, MR .

NEUROLOGY, 2000, 55 (04) :480-483

[6] Association between polymorphism in regulatory region of gene encoding tumour necrosis factor α and risk of Alzheimer's disease and vascular dementia:: a case-control study [J].

McCusker, SM ;

Curran, MD ;

Dynan, KB ;

McCullagh, CD ;

Urquhart, DD ;

Middleton, D ;

Patterson, CC ;

McIlroy, SP ;

Passmore, AP .

LANCET, 2001, 357 (9254) :436-439

[7]

MCKHANN G, 1984, NEUROLOGY, V34, P934

[8]

Nicoll JAR, 2000, ANN NEUROL, V47, P365, DOI 10.1002/1531-8249(200003)47:3<365::AID-ANA13>3.3.CO

[9]

2-7

[10] Investigation of association of 13 polymorphisms in eight genes in southeastern African American Alzheimer disease patients as compared to age-matched controls [J].

Perry, RT ;

Collins, JS ;

Harrell, LE ;

Acton, RT ;

Go, RCP .

AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 105 (04) :332-342

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