Copper deficiency as an anti-cancer strategy

被引：137

作者：

Goodman, VL

Brewer, GJ

Merajver, SD

机构：

[1] Univ Michigan, Sch Med, Div Hematol & Oncol, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Internal Med, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

关键词：

D O I：

10.1677/erc.0.0110255

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Copper is a tightly regulated trace element. Disruptions of copper homeostasis are rare and they cause serious disorders such as Wilson's disease and Menkes disease. Copper also plays an important role in promoting physiological and malignant angiogenesis. Formation of new blood vessels by a tumor enables tumor growth, invasion and metastasis. The copper chelator tetrathiomolybdate (TM), which quickly and effectively depletes copper stores, is under investigation as an anti-angiogenic agent. Promising results in vitro, in pre-clinical animal models and in an early (phase 1) clinical trial have led to ongoing phase 11 evaluation of TM in patients with advanced cancers.

引用

页码：255 / 263

页数：9

共 69 条

[1]

ALESSANDRI G, 1984, MICROCIRC ENDOTH LYM, V1, P329

[2]

As the Commission on Intellectual Property Rights (UK) notes, 2000, COMM INT PROP RIGHTS, P78

[3] SPECIFIC BINDING OF ANGIOGENIN TO CALF PULMONARY-ARTERY ENDOTHELIAL-CELLS [J].