Study of host-pathogen interactions to identify sustainable vaccine strategies to Marek's disease

被引：26

作者：

Baaten, BJG ^{[1
]}

Butter, C ^{[1
]}

Davison, T ^{[1
]}

机构：

[1] Inst Anim Hlth, Newbury RG20 7NN, Berks, England

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2004年 / 100卷 / 3-4期

关键词：

chicken; herpesvirus; immunity; Marek's disease; vaccine;

D O I：

10.1016/j.vetimm.2004.04.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Marek's disease virus is a highly cell-associated, lymphotropic alpha-herpesvirus that causes paralysis and neoplastic disease in chickens. The disease has been contained by vaccination with attenuated viruses and provides the first evidence for a malignant cancer being controlled by an antiviral vaccine. Marek's disease pathogenesis is complex, involving cytolytic and latent infection of lymphoid cells and oncogenic transformation of CD4(+) T cells in susceptible chickens. Innate and adaptive immune responses develop in response to infection, but infection of lymphocytes results in immunosuppressive effects. The remarkable ability of MDV to escape immune responses by interacting with, and down-regulating, some key aspects of the immune system will be discussed in the context of genetic resistance. Resistance conferred by vaccination and the implications of targeting replicative stages of the virus will also be examined. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：165 / 177

页数：13

共 150 条

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