Longitudinal changes of defensive and offensive factors in focal cerebral ischemia-reperfusion in rats

被引：21

作者：

Hu, Ming ^{[1
]}

Zhang, Xiangjian ^{[1
]}

Liu, Wei ^{[1
]}

Cui, Haiying ^{[1
]}

Di, Nan ^{[1
]}

机构：

[1] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang 050000, Hebei, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2009年 / 79卷 / 06期

关键词：

Cerebral ischemia-reperfusion injury; Behavior tests; Brain edema; Neuroprotection; Stroke; FACTOR-B-CHAIN; GROWTH-FACTOR; ARTERY OCCLUSION; WATER TRANSPORT; BRAIN EDEMA; AQUAPORIN-4; EXPRESSION; 5-LIPOXYGENASE; CYCLOOXYGENASE; CRANIECTOMY;

D O I：

10.1016/j.brainresbull.2009.05.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cerebral ischemia-reperfusion injury remains a major medical problem due to the lack of effective treatment. The mechanism of brain injury is still unknown. The defensive and offensive factors, such as platelet-derived growth factor-BB (PDGF-BB), 5-lipoxygenase (5-LO), aquaporin-4 (AQP-4) and insulin-like growth factor-1 (IGF-1) may play important roles. So far, only individual factors were reported. What are the relationships among them in brain ischemia-reperfusion injury remains obscure. The present study is to investigate simultaneously the expression of PDGF-BB, 5-LO, AQP-4 and IGF-1 in middle cerebral artery occlusion/reperfusion (MCAO/R) in rats. We found that 5-LO and IGF-1 reached the peak level at 24 h after reperfusion, AQP-4 at 72 h and PDGF-BB at 7 days. With these results we inferred that both defensive factors, such as PDGF-BB, AQP-4 and IGF-1, and offensive factor, like 5-LO, play some roles in the ischemia-reperfusion injury. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：371 / 375

页数：5

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