Possible novel targets for therapeutic angiogenesis

被引：29

作者：

Cristofaro, Brunella ^{[1
]}

Emanueli, Costanza ^{[1
]}

机构：

[1] Univ Bristol, Bristol Heart Inst, Div Expt Cardiovasc Med, Bristol, Avon, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 02期

关键词：

ENDOTHELIAL PROGENITOR CELLS; BONE MORPHOGENETIC PROTEINS; GROWTH-FACTOR; SONIC-HEDGEHOG; NEUROTROPHIC FACTOR; CARDIOVASCULAR DEVELOPMENT; VASCULAR MORPHOGENESIS; NETRIN RECEPTOR; NOTCH PATHWAY; EPH RECEPTORS;

D O I：

10.1016/j.coph.2008.11.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An increasing number of studies about the molecular basis of angiogenesis are rapidly disclosing novel signal pathways involved in the blood vessel formation process. This review will focus on bone morphogenic proteins, Hedgehog, Notch, ephrins, neuropilins, neurotrophins and netrins. These recently discovered angiogenesis mediators are involved in vascular development during embryogenesis and, interestingly, they are shared between the nervous and vascular systems. They represent new potential targets in the vasculature and suggest novel therapeutic opportunities.

引用

页码：102 / 108

页数：7

共 75 条

[1] Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
Adams, RH
Wilkinson, GA
Weiss, C
Diella, F
Gale, NW
Deutsch, U
Risau, W
Klein, R
[J]. GENES & DEVELOPMENT, 1999, 13 (03) : 295 - 306
[2] Sertoli cell signaling by Desert hedgehog regulates the male germline
Bitgood, MJ
Shen, LY
McMahon, AP
[J]. CURRENT BIOLOGY, 1996, 6 (03) : 298 - 304
[3] HEDGEHOG AND BMP GENES ARE COEXPRESSED AT MANY DIVERSE SITES OF CELL-CELL INTERACTION IN THE MOUSE EMBRYO
BITGOOD, MJ
MCMAHON, AP
[J]. DEVELOPMENTAL BIOLOGY, 1995, 172 (01) : 126 - 138
[4] Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo
Cantarella, G
Lempereur, L
Presta, M
Ribatti, D
Lombardo, G
Lazarovici, P
Zappalà, G
Pafumi, C
Bernardini, R
[J]. FASEB JOURNAL, 2002, 16 (08) : 1307 - +
[5] CAPORALI A, 2009, PHYSIOL REV, V89, P1
[6] Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis -: Implications for diabetes-induced impaired neovascularization in ischemic limb muscles
Caporali, Andrea
Pani, Elisabetta
Horrevoets, Anton J. G.
Kraenkel, Nicolle
Oikawa, Atsuhiko
Sala-Newby, Graciela B.
Meloni, Marco
Cristofaro, Brunella
Graiani, Gallia
Leroyer, Aurelie S.
Boulanger, Chantal M.
Spinetti, Gaia
Yoon, Sung Ok
Madeddu, Paolo
Emanueli, Costanza
[J]. CIRCULATION RESEARCH, 2008, 103 (02) : E15 - E26
[7] Chang H, 1999, DEVELOPMENT, V126, P1631
[8] Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, MV
[J]. NATURE REVIEWS NEUROSCIENCE, 2003, 4 (04) : 299 - 309
[9] Bone morphogenetic proteins
Chen, D
Zhao, M
Mundy, GR
[J]. GROWTH FACTORS, 2004, 22 (04) : 233 - 241
[10] CONLON RA, 1995, DEVELOPMENT, V121, P1533

← 1 2 3 4 5 6 7 8 →