Overrepresentation of the short arm of chromosome 12 in seminoma and nonseminoma groups of testicular germ cell tumors

被引：12

作者：

Pienkowska-Grela, B

Grygalewicz, B

Bregula, U

机构：

[1] Maria Sklodowska Curie Mem Canc Ctr, Cytogenet Lab, PL-02781 Warsaw, Poland

[2] Inst Oncol, PL-02781 Warsaw, Poland

来源：

CANCER GENETICS AND CYTOGENETICS | 2002年 / 134卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(01)00619-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The amplification of the short arm of the chromosome 12, especially as the it 12p) marker chromosome, has been found to be a highly nonrandom chromosome abnormality associated with testicular germ cell tumors (TGCT). A series of adult TGCT consisting of seven seminomas (SE) and eight nonseminomas (NS) was analyzed by conventional cytogenetics and fluorescent in situ hybridization. Multiplied chromosome 12 material originating from typical i(12p) and from other markers carrying chromosome 12-derived material was found in almost all analyzed tumors (6 of 7 SE cases and 8 of 8 NS cases). Heterogeneity in the copy number of i(12p) and other 12p-derived markers, as well as chromosome 12 aneuploidy. were higher in NS tumors than in SE. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：102 / 108

页数：7

共 27 条

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