Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review

被引：381

作者：

Palomba, Stefano ^{[1
]}

Falbo, Angela ^{[1
]}

Zullo, Fulvio ^{[1
]}

Orio, Francesco, Jr. ^{[2
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Gynecol & Obstet, I-88100 Catanzaro, Italy

[2] Univ Parthenope Naples, I-80131 Naples, Italy

来源：

ENDOCRINE REVIEWS | 2009年 / 30卷 / 01期

关键词：

ACTIVATED PROTEIN-KINASE; GROWTH-FACTOR-I; QUALITY-OF-LIFE; ANTIDIABETIC DRUG METFORMIN; INSULIN-SENSITIZING AGENTS; FATTY LIVER-DISEASE; RANDOMIZED CONTROLLED-TRIAL; TYPE-2; DIABETES-MELLITUS; FACTOR-BINDING PROTEIN-1; NORMAL-WEIGHT WOMEN;

D O I：

10.1210/er.2008-0030

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin resistant, metformin was introduced in clinical practice to treat these patients also. Moreover, metformin's effect has other targets beside its insulin-sensitizing action. The present review was aimed at describing all evidence-based and potential uses of metformin in PCOS patients. In particular, we will analyze the uses of metformin not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome. (Endocrine Reviews 30: 1-50, 2009)

引用

页码：1 / 50

页数：50

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