The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial

BackgroundDiabetes mellitus is a common metabolic disorders in human and affect a lot of people around the world. Curcumin is a component of turmeric and in many studies therapeutic effects such as anti-hypertensive, anti-hyperlipidemia, anti-hyperglycemia for this substance are shown.AimThe aim of this study was to investigate the effect of curcumin supplementation on anthropometric indices glycemic control and oxidative stress in overweight patients with type 2 diabetes.Materials and methodsIn this randomized, double-blind, placebo-controlled trial, 53 participants with type 2 diabetes were divided randomly into the experimental and control groups to receive either 1500mg curcumin or placebo capsule three times in a day for 10weeks.ResultSupplementation with curcumin in type 2 diabetes compare to placebo causes a significant changes in mean weight (-0.640.22 vs. 0.190.37 p<0.05), body mass index (BMI) (0.3 +/- 0.03 vs. 0.1 +/- 0 p<0.05), waist circumference (WC) (-1.2 +/- 0.4 vs. -0.43 +/- 0.11 p<0.05) and fasting blood sugar (FBS) (-7 +/- 2 vs. 3 +/- 0.2 p<0.05) but did not show any difference for hemoglobin A1c (HbA1c), insulin, malondialdehyde (MDA), total antioxidant capacity (TAC), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and pancreatic B cell function (HOMA-B) at end of study.Conclusion p id=Par5 This study indicated that daily administration of 1500mg curcumin has positive effects in reducing fasting blood glucose and weight in patients with type 2 diabetes. p id=Par6 Trial registration NCT02529982. Registered 19 August 2015, http://www.clinicaltrial.gov