Renal transplantation in patients with Alport syndrome

被引：75

作者：

Kashtan, Clifford E.

机构：

[1] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Childrens Hosp Fairview, Minneapolis, MN USA

来源：

PEDIATRIC TRANSPLANTATION | 2006年 / 10卷 / 06期

关键词：

alport syndrome; renal transplantation; type IV collagen; anti-GBM nephritis;

D O I：

10.1111/j.1399-3046.2006.00528.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

For pediatric kidney transplant physicians, two aspects of Alport syndrome set the disease apart from other causes of terminal renal failure. First, an understanding of the genetics of Alport syndrome is needed to make appropriate decisions regarding potential related kidney donors to Alport patients requiring renal transplantation. Second, renal transplantation for Alport syndrome may be complicated by post-transplant anti-GBM nephritis, a problem that is nearly unique to this disease. This review discusses these aspects of Alport syndrome and attempts to provide rational recommendations for clinicians.

引用

收藏

页码：651 / 657

页数：7

相关论文

共 55 条

[1]

DELETIONS IN THE COL4A5 COLLAGEN GENE IN X-LINKED ALPORT SYNDROME - CHARACTERIZATION OF THE PATHOLOGICAL TRANSCRIPTS IN NONRENAL CELLS AND CORRELATION WITH DISEASE EXPRESSION [J].

ANTIGNAC, C ;

KNEBELMANN, B ;

DROUOT, L ;

GROS, F ;

DESCHENES, G ;

HORSCAYLA, MC ;

ZHOU, J ;

TRYGGVASON, K ;

GRUNFELD, JP ;

BROYER, M ;

GUBLER, MC .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) :1195-1207

[2]

BERARDINELLI L, 1990, CONTRIB NEPHROL, V80, P131

[3]

Determination of the genomic structure of the COL4A4 gene and of novel mutations causing autosomal recessive Alport syndrome [J].

Boye, E ;

Mollet, G ;

Forestier, L ;

Cohen-Solal, L ;

Heidet, H ;

Cochat, P ;

Grünfeld, JP ;

Palcoux, JB ;

Gubler, MC ;

Antignac, C .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (05) :1329-1340

[4]

Targets of alloantibodies in Alport anti-glomerular basement membrane disease after renal transplantation [J].

Brainwood, D ;

Kashtan, C ;

Gubler, MC ;

Turner, AN .

KIDNEY INTERNATIONAL, 1998, 53 (03) :762-766

[5]

Retransplantation in Alport post-transplant anti-GBM disease [J].

Browne, G ;

Brown, PAJ ;

Tomson, CRV ;

Fleming, S ;

Allen, A ;

Herriot, R ;

Pusey, CD ;

Rees, AJ ;

Turner, AN .

KIDNEY INTERNATIONAL, 2004, 65 (02) :675-681

[6]

Mutations in the COL4A4 gene in thin basement membrane disease [J].

Buzza, M ;

Dagher, H ;

Wang, YY ;

Wilson, D ;

Babon, JJ ;

Cotton, RG ;

Savige, J .

KIDNEY INTERNATIONAL, 2003, 63 (02) :447-453

[7]

Identification of a new mutation in the α4(IV) collagen gene in a family with autosomal dominant Alport syndrome and hypercholesterolaemia [J].

Ciccarese, M ;

Casu, D ;

Wong, FK ;

Faedda, R ;

Arvidsson, S ;

Tonolo, G ;

Luthman, H ;

Satta, A .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (10) :2008-2012

[8]

ASSOCIATION OF THIN GLOMERULAR-BASEMENT-MEMBRANE WITH OTHER GLOMERULOPATHIES [J].

COSIO, FG ;

FALKENHAIN, ME ;

SEDMAK, DD .

KIDNEY INTERNATIONAL, 1994, 46 (02) :471-474

[9]

Identification of post-transplant anti-alpha 5(IV) collagen alloantibodies in X-linked Alport syndrome [J].

Dehan, P ;

VandenHeuvel, LPWJ ;

Smeets, HJM ;

Tryggvason, K ;

Foidart, JM .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1996, 11 (10) :1983-1988

[10]

DIAZ JI, 1994, ARCH PATHOL LAB MED, V118, P728

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