Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis

被引：61

作者：

Burska, Agata N. ^{[1
,2
]}

Hunt, Laura ^{[1
,2
]}

Boissinot, Marjorie ^{[3
]}

Strollo, Rocky ^{[4
]}

Ryan, Brent J. ^{[5
]}

Vital, Ed ^{[1
,2
]}

Nissim, Ahuva ^{[4
]}

Winyard, Paul G. ^{[6
]}

Emery, Paul ^{[1
,2
]}

Ponchel, Frederique ^{[1
,2
]}

机构：

[1] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Dis, Leeds LS9 7TF, W Yorkshire, England

[2] Leeds Trust Teaching Hosp, NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds LS9 7TF, W Yorkshire, England

[3] Univ Leeds, Leeds Inst Canc & Pathol, Leeds LS9 7TF, W Yorkshire, England

[4] Univ London, Ctr Biochem Pharmacol Res Unit, Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England

[5] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

[6] Univ Exeter, Sch Med, Exeter EX1 2LU, Devon, England

来源：

MEDIATORS OF INFLAMMATION | 2014年 / 2014卷

关键词：

CYCLIC CITRULLINATED PEPTIDE; LOW-DENSITY-LIPOPROTEIN; ANTICITRULLINATED PROTEIN ANTIBODIES; GLYCATION END-PRODUCTS; COLLAGEN TYPE-II; HUMAN EPIDERMIS FILAGGRIN; CHRONIC-RENAL-FAILURE; STRESS MARKER LEVELS; SYNOVIAL-FLUID; OXIDATIVE STRESS;

D O I：

10.1155/2014/492873

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Autoantibodies have been associated with human pathologies for a long time, particularly with autoimmune diseases (AIDs). Rheumatoid factor (RF) is known since the late 1930s to be associated with rheumatoid arthritis (RA). The discovery of anticitrullinated protein antibodies in the last century has changed this and other posttranslational modifications (PTM) relevant to RA have since been described. Such PTM introduce neoepitopes in proteins that can generate novel autoantibody specificities. The recent recognition of these novel specificities in RA provides a unique opportunity to understand human B-cell development in vivo. In this paper, we will review the three of the main classes of PTMs already associated with RA: citrullination, carbamylation, and oxidation. With the advancement of research methodologies it should be expected that other autoantibodies against PTM proteins could be discovered in patients with autoimmune diseases. Many of such autoantibodies may provide significant biomarker potential.

引用

页数：19

共 257 条

[1]

Neuronal PAD4 expression and protein citrullination: Possible role in production of autoantibodies associated with neurodegenerative disease [J].