Fluorescence diffuse optical tomography using upconverting nanoparticles

被引：48

作者：

Xu, Can T. ^{[1
]}

Axelsson, Johan ^{[1
]}

Andersson-Engels, Stefan ^{[1
]}

机构：

[1] Lund Univ, Dept Phys, S-22100 Lund, Sweden

来源：

APPLIED PHYSICS LETTERS | 2009年 / 94卷 / 25期

基金：

瑞典研究理事会;

关键词：

biological tissues; fluorescence; nanobiotechnology; nanoparticles; optical tomography; phantoms; photoluminescence; sodium compounds; thulium; ytterbium; yttrium compounds; SMALL ANIMALS; QUANTUM DOTS;

D O I：

10.1063/1.3156857

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT.

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页数：3

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