Computational Analysis of Human Adenovirus Type 22 Provides Evidence for Recombination among Species D Human Adenoviruses in the Penton Base Gene

被引：44

作者：

Robinson, Christopher M. ^{[1
]}

Rajaiya, Jaya ^{[1
]}

Walsh, Michael P. ^{[2
]}

Seto, Donald ^{[2
]}

Dyer, David W. ^{[3
]}

Jones, Morris S. ^{[4
]}

Chodosh, James ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Dept Ophthalmol,Howe Lab, Boston, MA 02114 USA

[2] George Mason Univ, Dept Bioinformat & Computat Biol, Manassas, VA USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73190 USA

[4] David Grant USAF Med Ctr, Clin Investigat Facil, Travis, CA USA

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 17期

关键词：

ACUTE RESPIRATORY-DISEASE; BIOINFORMATICS ANALYSIS; CROSSOVER SITES; DNA-SEQUENCE; INFECTION; KERATOCONJUNCTIVITIS; REPLICATION; EVOLUTION; PROTEINS; VECTORS;

D O I：

10.1128/JVI.00786-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recombination in human adenoviruses (HAdV) may confer virulence upon an otherwise nonvirulent strain. The genome sequence of species D HAdV type 22 (HAdV-D22) revealed evidence for recombination with HAdV-D19 and HAdV-D37 within the capsid penton base gene. Bootscan analysis demonstrated that recombination sites within the penton base gene frame the coding sequences for the two external hypervariable loops in the protein. A similar pattern of recombination was evident within other HAdV-D types but not other HAdV species. Further study of recombination among HAdVs is needed to better predict possible recombination events among wild-type viruses and adenoviral gene therapy vectors.

引用

页码：8980 / 8985

页数：6

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