New glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber

被引：26

作者：

Afiyatullov, SS ^{[1
]}

Kalinovsky, AI ^{[1
]}

Kuznetsova, TA ^{[1
]}

Pivkin, MV ^{[1
]}

Prokof'eva, NG ^{[1
]}

Dmitrenok, PS ^{[1
]}

Elyakov, GB ^{[1
]}

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far E Branch, Moscow 117901, Russia

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 06期

关键词：

D O I：

10.1021/np0305324

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new diterpene glycosides, virescenosides R (1), S (2), T (3), and U (4), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures have been elucidated on the basis of HRFABMS, 1D and 2D NMR (H-1, C-13, DEPT, COSY-45, COSY-RCT, HSQC, HMBC, and NOESY spectra), and the results of acidic hydrolysis as 19-O-{beta-D-glucopyranosyl(1-->6)-beta-D-altropyranosyl}-isopimara-7,15-diene-2alpha,3beta-diol (1), 19-O-beta-D-altropyranosyl-3-oxo-isopimara-8(14),15-diene-7alpha-ol (2), 19-O-beta-D-altropyranosyl-3,7-dioxo-isopimara-8,15-diene (3), and 19-O-beta-D-altropyranosyl-3,7-dioxo-isopimara-8(14),15-diene (4). The cytotoxic activity of the virescenosides was examined.

引用

页码：1047 / 1051

页数：5

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