IGL-1 solution in kidney transplantation: first mufti-center study

被引:48
作者
Codas, Ricardo
Petruzzo, Palmina [1 ,2 ]
Morelon, Emmanuel [3 ,4 ]
Lefrancois, Nicole [4 ]
Danjou, Fabrice [5 ]
Berthillot, Celine
Contu, Paolo [5 ]
Espa, Michele
Martin, Xavier [3 ]
Badet, Lionel [3 ]
机构
[1] Hop Edouard Herriot, Serv Urol & Transplantat, Dept Urol & Transplant Surg, Centaure Network, F-69437 Lyon, France
[2] Univ Cagliari, Dept Surg, Cagliari, Italy
[3] Univ Lyon 1, F-69365 Lyon, France
[4] Hop Edouard Herriot, Centaure Network, Dept Nephrol & Transplantat, F-69437 Lyon, France
[5] Univ Cagliari, Dept Publ Hlth, Cagliari, Italy
关键词
clinical trial; IGL-1; solution; ischemia/reperfusion injury; kidney transplantation; preservation solution; COLD-STORAGE SOLUTION; POLYETHYLENE-GLYCOL; LIPID-PEROXIDATION; LOW-POTASSIUM; RISK-FACTORS; PRESERVATION; REPERFUSION;
D O I
10.1111/j.1399-0012.2009.00959.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
IGL-1 solution is characterized by inversion of K+ and Na+ concentrations in the University Wisconsin (UW) solution and polyethylene glycol 35 (PEG 35) substitution for hydroxy ethyl starch. In this prospective study, 121 patients transplanted with kidneys preserved in IGL-1 solution were compared to 102 patients grafted with kidneys preserved in UW solution. Serum creatinine and creatinine clearance, delayed graft function (DGF) and rejection episodes, patient and graft survival were evaluated in the first post-transplant year. Groups were comparable regarding to donor and recipient characteristics. Median creatinine levels were significantly lower in IGL-1 group from day 6 to day 14 and it decreased more rapidly in the IGL-1 group (from day 4 to day 15: p < 0.05). Creatinine clearance values were usually higher in the IGL-1 group for the first 15 d. During the follow-up period serum creatinine concentrations were lower in IGL-1 group at one, three, six and 12 months after transplantation (p = 0.04; p = 0.06, p = 0.01 and p = 0.08, respectively) while creatinine clearance values were similar during the follow-up. No significant difference in DGF and rejection rates as well as in patient and graft survival was shown between the two groups. Kidneys preserved in IGL-1 solution showed to have the same function as kidneys preserved in UW solution.
引用
收藏
页码:337 / 342
页数:6
相关论文
共 13 条
  • [1] Kidney preservation with IGL-1 solution:: A preliminary report
    Badet, L
    Petruzzo, P
    Lefrançois, N
    McGregor, B
    Espa, M
    Berthillot, C
    Danjou, F
    Contu, P
    Aissa, AH
    Virieux, SR
    Colpart, JJ
    Martin, X
    [J]. TRANSPLANTATION PROCEEDINGS, 2005, 37 (01) : 308 - 311
  • [2] Effect of IGL-1, a new preservation solution, on kidney grafts (a pre-clinical study)
    Badet, L
    Ben Abdennebi, H
    Petruzzo, P
    McGregor, B
    Espa, M
    Hadj-Aissa, A
    Ramella-Virieux, S
    Steghens, JP
    Portoghese, F
    Martin, X
    [J]. TRANSPLANT INTERNATIONAL, 2004, 17 (12) : 815 - 821
  • [3] PRINCIPLES OF SOLID-ORGAN PRESERVATION BY COLD-STORAGE
    BELZER, FO
    SOUTHARD, JH
    [J]. TRANSPLANTATION, 1988, 45 (04) : 673 - 676
  • [4] High-Na+ low-K+ UW cold storage solution reduces reperfusion injuries of the rat liver graft
    Ben Abdennebi, H
    Steghens, JP
    Margonari, J
    Ramella-Virieux, S
    Barbieux, A
    Boillot, O
    [J]. TRANSPLANT INTERNATIONAL, 1998, 11 (03) : 223 - 230
  • [5] A preservation solution with polyethylene glycol and calcium:: a possible multiorgan liquid
    Ben Abdennebi, H
    Steghens, JP
    Hadj-Aïssa, A
    Barbieux, A
    Ramella-Virieux, S
    Gharib, C
    Boillot, O
    [J]. TRANSPLANT INTERNATIONAL, 2002, 15 (07) : 348 - 354
  • [6] Preservation of steatotic livers in IGL-1 solution
    Ben Mosbah, Ismail
    Rosello-Catafau, Joan
    Franco-Gou, Rosa
    Ben Abdennebi, Hassen
    Saidane, Dalila
    Ramella-Virieux, Silvina
    Boillot, Olivier
    Peralta, Carmen
    [J]. LIVER TRANSPLANTATION, 2006, 12 (08) : 1215 - 1223
  • [7] First human face allograft:: early report
    Devauchelle, Bernard
    Badet, Lionel
    Lengele, Benoit
    Morelon, Emmanuel
    Testelin, Sylvie
    Michallet, Mauricette
    D'Hauthuille, Cedric
    Dubernard, Jean-Michel
    [J]. LANCET, 2006, 368 (9531) : 203 - 209
  • [8] Polyethylene glycol reduces early and long-term cold ischemia-reperfusion and renal medulla injury
    Faure, JP
    Hauet, T
    Han, ZQ
    Goujon, JM
    Petit, I
    Mauco, G
    Eugene, M
    Carretier, M
    Papadopoulos, V
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 302 (03) : 861 - 870
  • [9] Beneficial effects of low-potassium and polyethylene glycol solution on renal lipid peroxidation during 48-hour cold storage and normothermic reperfusion
    Hauet, T
    Baumert, H
    Faure, JP
    Bardou, A
    Beguinot, S
    Gibelin, H
    Ben Amor, I
    Germonville, T
    Caritez, JC
    Carretier, M
    Eugene, M
    [J]. TRANSPLANTATION PROCEEDINGS, 1998, 30 (06) : 2798 - 2799
  • [10] Risk factors for delayed graft function in cadaveric kidney transplantation - A prospective study of renal function and graft survival after preservation with University of Wisconsin solution in multi-organ donors
    Koning, OHJ
    Ploeg, RJ
    VanBockel, JH
    Groenewegen, M
    VanderWoude, FJ
    Persijn, GG
    Hermans, J
    [J]. TRANSPLANTATION, 1997, 63 (11) : 1620 - 1628