Evolution of the immune system in humans from infancy to old age

被引：1323

作者：

Simon, A. Katharina ^{[1
]}

Hollander, Georg A. ^{[2
]}

McMichael, Andrew ^{[3
]}

机构：

[1] Univ Oxford, Weatherall Inst Mol Med, Nuffield Dept Med, Oxford OX3 9DS, England

[2] Univ Oxford, Weatherall Inst Mol Med, Dept Paediat, Oxford OX3 9DS, England

[3] Univ Oxford, Nuffield Dept Med Res Bldg, Oxford OX3 7FZ, England

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2015年 / 282卷 / 1821期

基金：

英国惠康基金;

关键词：

adaptive immunity; innate immunity; infections; NECROSIS-FACTOR-ALPHA; REGULATORY T-CELLS; DENDRITIC CELLS; GUT MICROBIOTA; TERM NEWBORNS; CORD BLOOD; B-CELL; PRETERM; ANTIGEN; LYMPHOCYTES;

D O I：

10.1098/rspb.2014.3085

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.

引用

页数：9

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