Changes in the alpha(2)-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

被引：61

作者：

Cho, HJ ^{[1
]}

Kim, DS ^{[1
]}

Lee, NH ^{[1
]}

Kim, JK ^{[1
]}

Lee, KM ^{[1
]}

Han, KS ^{[1
]}

Kang, YN ^{[1
]}

Kim, KJ ^{[1
]}

机构：

[1] CHUNGNAM NATL UNIV, SCH MED, DEPT PHYSIOL, TAEJON, SOUTH KOREA

来源：

NEUROREPORT | 1997年 / 8卷 / 14期

关键词：

alpha(2)-adrenergic receptor; dorsal root ganglion; gene expression; in situ hybridization; neuropathic pain; reverse transcriptase polymerase chain reaction;

D O I：

10.1097/00001756-199709290-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined changes in expression of genes coding for alpha(2)-AR subtypes in the dorsal root gan on (DRG) in rat model (spinal nerve ligation) neuropathic pain. The present study demonstrates that the majority of DRG neurons express alpha(2)C-AR mRNA and a small proportion of neurons express alpha(2)A-AR mRNA, while neurons express alpha(2)B-AR mRNA in non-operated animals. In addition, alpha(2)C- and alpha(2)A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that alpha(2)A- and alpha(2)C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.

引用

页码：3119 / 3122

页数：4

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