Mammalian CELF/Bruno-like RNA-binding proteins:: molecular characteristics and biological functions

被引：124

作者：

Barreau, Carine ^{[1
]}

Paillard, Luc ^{[1
]}

Mereau, Agnes ^{[1
]}

Osborne, H. Beverley ^{[1
]}

机构：

[1] Univ Rennes 1, CNRS, UMR 6061, IFR 140, 2,Ave Leon Bernard,CS 34317, F-35043 Rennes, France

来源：

BIOCHIMIE | 2006年 / 88卷 / 05期

基金：

澳大利亚研究理事会;

关键词：

alternative splicing; translation; mRNA stability;

D O I：

10.1016/j.biochi.2005.10.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammals, the CELF/Bruno-like family of RNA-binding proteins contains six members. The founder members of the family are the CUG-BPI (CELF 1) and ETR-3 (CELF2) proteins. Four other members have been identified mainly by sequence similarity. The founder members were cloned or identified in a number of laboratories which has lead to a profusion of names and two separate naming systems. In addition, different members of the CELF/Bruno-like protein family have been shown to be implicated in two major post-transcriptional regulatory processes, namely the alternative splicing and the control of translation and stability of target mRNAs.. Several studies have indicated a certain functional redundancy between the CELF proteins in fulfilling these functions. The multiplicity of gene names and the eventual functional redundancy is a source of potential confusion in published work. We present here a synthetic picture of the present situation and, where possible, models are proposed that can account for the data obtained in the various laboratories with different biological models. Furthermore, we have highlighted some important questions that still need to be resolved. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：515 / 525

页数：11