Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche

被引：305

作者：

Hayakawa, Yoku ^{[1
]}

Ariyama, Hiroshi ^{[1
]}

Stancikova, Jitka ^{[2
]}

Sakitani, Kosuke ^{[1
]}

Asfaha, Samuel ^{[1
]}

Renz, Bernhard W. ^{[1
,14
]}

Dubeykovskaya, Zinaida A. ^{[1
]}

Shibata, Wataru ^{[1
]}

Wang, Hongshan ^{[1
]}

Westphalen, Christoph B. ^{[1
]}

Chen, Xiaowei ^{[1
]}

Takemoto, Yoshihiro ^{[1
]}

Kim, Woosook ^{[1
]}

Khurana, Shradha S. ^{[1
]}

Tailor, Yagnesh ^{[1
]}

Nagar, Karan ^{[1
]}

Tomita, Hiroyuki ^{[3
]}

Hara, Akira ^{[3
]}

Sepulveda, Antonia R. ^{[4
]}

Setlik, Wanda ^{[5
]}

Gershon, Michael D. ^{[5
]}

Saha, Subhrajit ^{[6
]}

Ding, Lei ^{[7
,8
]}

Shen, Zeli ^{[9
]}

Fox, James G. ^{[9
]}

Friedman, Richard A. ^{[10
,11
]}

Konieczny, Stephen F. ^{[12
,13
]}

Worthley, Daniel L. ^{[1
]}

Korinek, Vladimir ^{[2
]}

Wang, Timothy C. ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Med, Div Digest & Liver Dis, New York, NY 10032 USA

[2] Acad Sci Czech Republ, Inst Mol Genet, Dept Cell & Dev Biol, CR-14220 Prague, Czech Republic

[3] Gifu Univ, Grad Sch Med, Dept Tumor Biol, Gifu 5011194, Japan

[4] Columbia Univ, Coll Phys & Surg, Dept Pathol, Div Clin Pathol & Cell Biol, New York, NY 10032 USA

[5] Columbia Univ, Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USA

[6] Albert Einstein Coll Med, Dept Radiat Oncol, Bronx, NY 10461 USA

[7] Columbia Univ, Coll Phys & Surg, Dept Rehabil & Regenerat Med, New York, NY 10032 USA

[8] Columbia Univ, Coll Phys & Surg, Dept Microbiol & Immunol, New York, NY 10032 USA

[9] MIT, Div Comparat Med, Cambridge, MA 02139 USA

[10] Columbia Univ, Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr Biomed Informa, New York, NY 10032 USA

[11] Columbia Univ, Coll Phys & Surg, Dept Biomed Informat, New York, NY 10032 USA

[12] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA

[13] Purdue Univ, Purdue Ctr Canc Res, W Lafayette, IN 47907 USA

[14] Hosp Univ Munich, Dept Gen Visceral Transplantat Vasc & Thorac Surg, D-81377 Munich, Germany

来源：

CANCER CELL | 2015年 / 28卷 / 06期

关键词：

INNATE LYMPHOID-CELLS; E-CADHERIN; PROGENITOR CELLS; CHIEF CELLS; CANCER; BONE; STOMACH; MAINTENANCE; MUTATIONS; WNT5A;

D O I：

10.1016/j.ccell.2015.10.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin. Diffuse-type cancer development is dependent on inflammation mediated by Cxcl12(+) endothelial cells and Cxcr4(+) gastric innate lymphoid cells (ILCs). These cells form the perivascular gastric stem cell niche, and Wnt5a produced from ILCs activates RhoA to inhibit anoikis in the E-cadherin-depleted cells. Targeting Cxcr4, ILCs, or Wnt5a inhibits diffuse-type gastric carcinogenesis, providing targets within the neoplastic gastric stem cell niche.

引用

页码：800 / 814

页数：15

共 54 条

[1]

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice [J].

Arnold, Katrin ;

Sarkar, Abby ;

Yram, Mary Anna ;

Polo, Jose M. ;

Bronson, Rod ;

Sengupta, Sumitra ;

Seandel, Marco ;

Geijsen, Niels ;

Hochedlinger, Konrad .

CELL STEM CELL, 2011, 9 (04) :317-329

[2]

Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine [J].

Bando, Jennifer K. ;

Liang, Hong-Erh ;

Locksley, Richard M. .

NATURE IMMUNOLOGY, 2015, 16 (02) :153-+

[3]

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro [J].

Barker, Nick ;

Huch, Meritxell ;

Kujala, Pekka ;

van de Wetering, Marc ;

Snippert, Hugo J. ;

van Es, Johan H. ;

Sato, Toshiro ;

Stange, Daniel E. ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

van den Brink, Stieneke ;

Korving, Jeroen ;

Abo, Arie ;

Peters, Peter J. ;

Wright, Nick ;

Poulsom, Richard ;

Clevers, Hans .

CELL STEM CELL, 2010, 6 (01) :25-36

[4]

Crypt stem cells as the cells-of-origin of intestinal cancer [J].

Barker, Nick ;

Ridgway, Rachel A. ;

van Es, Johan H. ;

van de Wetering, Marc ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

Clarke, Alan R. ;

Sansom, Owen J. ;

Clevers, Hans .

NATURE, 2009, 457 (7229) :608-U119

[5]

Comprehensive molecular characterization of gastric adenocarcinoma [J].

Bass, Adam J. ;

Thorsson, Vesteinn ;

Shmulevich, Ilya ;

Reynolds, Sheila M. ;

Miller, Michael ;

Bernard, Brady ;

Hinoue, Toshinori ;

Laird, Peter W. ;

Curtis, Christina ;

Shen, Hui ;

Weisenberger, Daniel J. ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Weinhold, Nils ;

Keiser, David P. ;

Bowlby, Reanne ;

Sipahimalani, Payal ;

Cherniack, Andrew D. ;

Getz, Gad ;

Liu, Yingchun ;

Noble, Michael S. ;

Pedamallu, Chandra ;

Sougnez, Carrie ;

Taylor-Weiner, Amaro ;

Akbani, Rehan ;

Lee, Ju-Seog ;

Liu, Wenbin ;

Mills, Gordon B. ;

Yang, Da ;

Zhang, Wei ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Gulley, Margaret ;

Piazuelo, M. Blanca ;

Schneider, Barbara G. ;

Kim, Jihun ;

Boussioutas, Alex ;

Sheth, Margi ;

Demchok, John A. ;

Rabkin, Charles S. ;

Willis, Joseph E. ;

Ng, Sam ;

Garman, Katherine ;

Beer, David G. ;

Pennathur, Arjun ;

Raphael, Benjamin J. ;

Wu, Hsin-Ta ;

Odze, Robert ;

Kim, Hark K. ;

Bowen, Jay .

NATURE, 2014, 513 (7517) :202-209

[6]

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia [J].

Buonamici, Silvia ;

Trimarchi, Thomas ;

Ruocco, Maria Grazia ;

Reavie, Linsey ;

Cathelin, Severine ;

Mar, Brenton G. ;

Klinakis, Apostolos ;

Lukyanov, Yevgeniy ;

Tseng, Jen-Chieh ;

Sen, Filiz ;

Gehrie, Eric ;

Li, Mengling ;

Newcomb, Elizabeth ;

Zavadil, Jiri ;

Meruelo, Daniel ;

Lipp, Martin ;

Ibrahim, Sherif ;

Efstratiadis, Argiris ;

Zagzag, David ;

Bromberg, Jonathan S. ;

Dustin, Michael L. ;

Aifantis, Iannis .

NATURE, 2009, 459 (7249) :1000-U129

[7]

Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening [J].

Carneiro, F ;

Huntsman, DG ;

Smyrk, TC ;

Owen, DA ;

Seruca, R ;

Pharoah, P ;

Caldas, C ;

Sobrinho-Simoes, M .

JOURNAL OF PATHOLOGY, 2004, 203 (02) :681-687

[8]

Wnt5a is essential for intestinal elongation in mice [J].

Cervantes, Sara ;

Yamaguchi, Terry P. ;

Hebrok, Matthias .

DEVELOPMENTAL BIOLOGY, 2009, 326 (02) :285-294

[9]

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches [J].

Ding, Lei ;

Morrison, Sean J. .

NATURE, 2013, 495 (7440) :231-235

[10]

Troy, a Tumor Necrosis Factor Receptor Family Member, Interacts With Lgr5 to Inhibit Wnt Signaling in Intestinal Stem Cells [J].

Fafilek, Bohumil ;

Krausova, Michaela ;

Vojtechova, Martina ;

Pospichalova, Vendula ;

Tumova, Lucie ;

Sloncova, Eva ;

Huranova, Martina ;

Stancikova, Jitka ;

Hlavata, Adela ;

Svec, Jiri ;

Sedlacek, Radislav ;

Luksan, Ondrej ;

Oliverius, Martin ;

Voska, Ludek ;

Jirsa, Milan ;

Paces, Jan ;

Kolar, Michal ;

Krivjanska, Maria ;

Klimesova, Klara ;

Tlaskalova-Hogenova, Helena ;

Korinek, Vladimir .

GASTROENTEROLOGY, 2013, 144 (02) :381-391

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