NY-ESO-1:: Review of an immunogenic tumor antigen

被引：281

作者：

Gnjatic, Sacha ^{[1
]}

Nishikawa, Hiroyoshi

Jungbluth, Achim A.

Guere, Ali O.

Ritter, Gerd

Jaeger, Elke

Chen, Yao-Tseng

Old, Lloyd J.

机构：

[1] Mem Sloan Kettering Canc Ctr, Ludwig Inst Canc Res, New York Branch, New York, NY 10021 USA

[2] Krankenhaus NW Frankfurt, Med Klin Hamatol Onkol 2, D-60488 Frankfurt, Germany

[3] Univ Zurich Hosp, Klin & Poliklin Onkol, CH-8091 Zurich, Switzerland

[4] Cornell Univ, Weill Med Coll, Dept Pathol, New York, NY 10021 USA

来源：

ADVANCES IN CANCER RESEARCH, VOL 95 | 2006年 / 95卷

关键词：

D O I：

10.1016/S0065-230X(06)95001-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the 9 years since its discovery, cancer-testis antigen NY-ESO-1 has made one of the fastest transitions from molecular, cellular, and immunological description to vaccine and immunotherapy candidate, already tested in various formulations in more than 30 clinical trials worldwide. Its main characteristic resides in its capacity to elicit spontaneous antibody and T-cell responses in a proportion of cancer patients. An overview of immunological findings and immunotherapeutic approaches with NY-ESO-1, as well the role of regulation in NY-ESO-1 immunogenicity, is presented here. (c) 2006 Elsevier Inc.

引用

页码：1 / 30

页数：30

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