Development of tuberculin reactivity and sensitization to M. Scrofulaceum and M. Fortuitum in children BCG-vaccinated at birth

被引:14
作者
Kröger, L [1 ]
Korppi, M
Pelkonen, J
Pietikäinen, M
Katila, ML
机构
[1] Kuopio Univ Hosp, Dept Paediat, FIN-70211 Kuopio, Finland
[2] Univ Kuopio, Dept Clin Microbiol, FIN-70211 Kuopio, Finland
[3] Kuopio Univ Hosp, Dept Clin Microbiol, Kuopio, Finland
[4] Publ Hlth Ctr, Siilinjarvi, Finland
关键词
Bacille Calmette-Guerin; children; environmental mycobacteria; sensitin; tuberculin;
D O I
10.1034/j.1399-3003.2000.15b26.x
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Since the incidence of tuberculosis is steadily declining in Finland and infections by environmental mycobacteria may be increasing, the aim of the present study was to evaluate the development of tuberculin reactivity and sensitization to environmental mycobacteria, Healthy Finnish schoolchildren aged 10.4-12.4 yrs (n=201) were tested with tuberculin purified protein derivative RT23, Mycobacterium scrofulaceum RS95 and M. fortuitum RS20 sensitins, The same children had been previously tested with the same antigens and methods at the age of 4-6 yrs in 1989. Rapid waning of tuberculin reactivity and decrease in sensitization to environmental mycobacteria were observed between 4-6 yrs. Both tuberculin and sensitin skin reaction sizes decreased significantly over the 6-yrs period. The mean tuberculin skin reaction size was 3.2 mm in diameter, which was significantly (p<0.001) smaller than the mean induration size (4.8 mm) at the age of 4-6 yrs. Similarly, the mean skin reaction sizes to M. scrofulaceum and M. fortuitum sensitins were 3.4 and 1.7 mm, respectively, which were significantly (p<0.001) smaller than 6 yrs earlier (mean 4.5 and 3.1 mm), The number of zero reactions to all antigens increased significantly during the follow-up period. Contacts with pets or farm animals were associated with larger reactions. In contrast, children suffering from allergic symptoms had smaller reactions. Contacts with mycobacteria, either with Mycobacterium tuberculosis or environmental mycobacteria, seem to be too rare to maintain tuberculin responsiveness and a high sensitivity to other mycobacteria. Different bacille Calmette-Guerin vaccine products and dosages used, the declining incidence of tuberculosis and geographical factors, which can influence environmental mycobacterial exposure, may explain the disparity between the present and previous Finnish studies.
引用
收藏
页码:382 / 387
页数:6
相关论文
共 38 条
[1]   Early BCG vaccination and development of atopy [J].
Alm, JS ;
Lilja, G ;
Pershagen, G ;
Scheynius, A .
LANCET, 1997, 350 (9075) :400-403
[2]  
BJERKEDAL T, 1966, AM J EPIDEMIOL, V85, P157
[3]  
BLEIKER MA, 1986, B INT UNION TUBERC L, V61, P86
[4]  
BULOW K, 1980, B INT UNION TUBERC L, V55, P100
[5]  
DASCALOPOULOS GA, 1995, EUR RESPIR J, V5, P715
[6]   Vaccines, genes and trials [J].
Fine, PEM .
GENETICS AND TUBERCULOSIS, 1998, 217 :57-72
[7]  
GOMSTOCK GW, 1988, AM REV RESPIR DIS, V138, P479
[8]  
GOSLEE S, 1976, AM REV RESPIR DIS, V113, P287
[9]  
HARO AS, 1998, TUBERCULOSIS RESP DI, V24, P1
[10]  
HORWITZ O, 1972, B WORLD HEALTH ORGAN, V47, P49