Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants

被引：46

作者：

Antia, U. ^{[1
]}

Lee, H. S. ^{[1
]}

Kydd, R. R. ^{[2
]}

Tingle, M. D. ^{[3
]}

Russell, B. R. ^{[1
]}

机构：

[1] Univ Auckland, Sch Pharm, Auckland 1, New Zealand

[2] Univ Auckland, Dept Pharmacol, Auckland 1, New Zealand

[3] Univ Auckland, Dept Psychol Med, Auckland 1, New Zealand

来源：

FORENSIC SCIENCE INTERNATIONAL | 2009年 / 186卷 / 1-3期

关键词：

BZP; Pharmacokinetics; Plasma; Urine; Metabolites; 1-BENZYLPIPERAZINE; DEXAMPHETAMINE; METABOLISM; URINE;

D O I：

10.1016/j.forsciint.2009.01.015

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

030101 [法学理论]; 030111 [法律史学]; 100218 [急诊医学];

摘要：

There have been many reports of benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) being used as recreational drugs which have been widely marketed in the form of 'party pills' since the late 1990's. However, there is no information currently available describing the pharmacokinetics of these drugs in humans. Human plasma concentrations of BZP were measured in blood and urine samples taken from healthy adults (n = 7) over 24 h following a 200 mg oral dose of BZP. Plasma concentrations of BZP were found to peak at 262 ng/mL (C(max)) and 75 min (T(max)). Plasma concentrations of the major metabolites of BZP, 4-OH BZP and 3-OH BZP, were found to peak at 7 ng/mL (at 60 min) and 13 ng/mL (at 75 min) respectively. The elimination half-life (t(1/2)) for BZP was found to be 5.5 h. Clearance (Cl/F) was found to be 99 L/h. The results of this study indicate that BZP may be detectable in plasma for up to 30 h following an oral dose. Additionally, several urinary metabolites can be detected. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：63 / 67

页数：5

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