In vitro susceptibility of Clostridium difficile clinical isolates from a multi-institutional outbreak in southern Quebec, Canada

被引:76
作者
Bourgault, Anne-Marie
Lamothe, Francois
Loo, Vivian G.
Poirier, Louise
机构
[1] Univ Montreal, Ctr Hosp, Hop St Luc, Dept Microbiol Med & Infectiol, Montreal, PQ H2X 3J4, Canada
[2] McGill Univ, Ctr Hlth, Montreal, PQ, Canada
[3] Hop Maison Neuve Rosemont, Montreal, PQ H1T 2M4, Canada
关键词
FIELD GEL-ELECTROPHORESIS; METRONIDAZOLE; EPIDEMIC; DIARRHEA; COLITIS; STRAIN; RISK;
D O I
10.1128/AAC.00479-06
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Clostridium difficile isolates from a 2004 outbreak in Quebec, Canada, were all found to be susceptible to metronidazole, vancomycin, rifampin, and meropenem but resistant to bacitracin, cefotaxime, ciprofloxacin, and levofloxacin, and most (> 80%) were resistant to ceftriaxone, clarithromycin, gatifiloxacin, and moxifiloxacin. The predominant NAP1 isolates were susceptible to clindamycin, while the NAP2 isolates were resistant.
引用
收藏
页码:3473 / 3475
页数:3
相关论文
共 17 条
[1]  
[Anonymous], M11A6 NCCLS
[2]   Prevalence and pathogenicity of Clostridium difficile in hospitalized patients - A french multicenter study [J].
Barbut, F ;
Corthier, G ;
Charpak, Y ;
Cerf, M ;
Monteil, H ;
Fosse, T ;
Trevoux, A ;
DeBarbeyrac, B ;
Boussougant, Y ;
Tigaud, S ;
Tytgat, F ;
Sedallian, A ;
Duborgel, S ;
Collignon, A ;
LeGuern, ME ;
Bernasconi, P ;
Petit, JC .
ARCHIVES OF INTERNAL MEDICINE, 1996, 156 (13) :1449-1454
[3]   The new Clostridium difficile -: What does it mean? [J].
Bartlett, JG ;
Perl, TM .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) :2503-2505
[4]  
CONTANT C, 1996, DIAGN MICROBIOL INFE, V25, P9
[5]   Pulsed-field gel electrophoresis can yield DNA fingerprints of degradation-susceptible Clostridium difficile strains [J].
Fawley, WN ;
Wilcox, MH .
JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (09) :3546-3547
[6]   Antibiotic activity against genotypically distinct and indistinguishable Clostridium difficile isolates [J].
Freeman, J ;
Wilcox, MH .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 47 (02) :244-246
[7]   Metronidazole for Clostridium difficile-associated disease:: Is it okay for mom? [J].
Gerding, DN .
CLINICAL INFECTIOUS DISEASES, 2005, 40 (11) :1598-1600
[8]   Antimicrobial susceptibility of polymerase chain reaction ribotypes of Clostridium difficile commonly isolated from symptomatic hospital patients in the UK [J].
John, R ;
Brazier, JS .
JOURNAL OF HOSPITAL INFECTION, 2005, 61 (01) :11-14
[9]   E test susceptibility testing of nosocomial Clostridium difficile isolates against metronidazole, vancomycin, fusidic acid and the novel agents moxifloxacin, gatifloxacin, and linezolid [J].
Leroi, MJ ;
Siarakas, S ;
Gottlieb, T .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2002, 21 (01) :72-74
[10]   Clostridium difficile:: a formidable foe [J].
Loo, VG ;
Libman, MD ;
Miller, MA ;
Bourgault, AM ;
Frenette, CH ;
Kelly, M ;
Michaud, S ;
Nguyen, T ;
Poirier, L ;
Vibien, A ;
Horn, R ;
Laflamme, PJ ;
René, P .
CANADIAN MEDICAL ASSOCIATION JOURNAL, 2004, 171 (01) :47-48