Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions

被引：279

作者：

Jensen, JB ^{[1
]}

Pedersen, LH

Hoiby, PE

Nielsen, LB

Hansen, TP

Folkenberg, JR

Riishede, J

Noordegraaf, D

Nielsen, K

Carlsen, A

Bjarklev, A

机构：

[1] Tech Univ Denmark, Res Ctr, COM, DK-2800 Lyngby, Denmark

[2] Bioneer AS, DK-2970 Horsholm, Denmark

[3] Crystal Fibre AS, DK-3460 Birkerod, Denmark

来源：

OPTICS LETTERS | 2004年 / 29卷 / 17期

关键词：

D O I：

10.1364/OL.29.001974

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate highly efficient evanescent-wave detection of fluorophore-labeled biomolecules in aqueous solutions positioned in the air holes of the microstructured part of a photonic crystal fiber. The air-suspended silica structures located between three neighboring air holes in the cladding crystal guide light with a large fraction of the optical field penetrating into the sample even at wavelengths in the visible range. An effective interaction length of several centimeters is obtained when a sample volume of less than 1 muL is used. (C) 2004 Optical Society of America.

引用

页码：1974 / 1976

页数：3

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