Age-associated declines in immune system development and function: causes, consequences, and reversal

被引:73
作者
Dorshkind, Kenneth [1 ]
Swain, Susan [2 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[2] Trudeau Inst Inc, Saranac Lake, NY 12983 USA
关键词
BONE-MARROW;
D O I
10.1016/j.coi.2009.07.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:404 / 407
页数:4
相关论文
共 6 条
  • [1] The ageing immune system: is it ever too old to become young again?
    Dorshkind, Kenneth
    Montecino-Rodriguez, Encarnacion
    Signer, Robert A. J.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2009, 9 (01) : 57 - 62
  • [2] Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
    Ju, Zhenyu
    Jiang, Hong
    Jaworski, Maike
    Rathinam, Chozhavendan
    Gompf, Anne
    Klein, Christoph
    Trumpp, Andreas
    Rudolph, K. Lenhard
    [J]. NATURE MEDICINE, 2007, 13 (06) : 742 - 747
  • [3] Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
    Knutson, Mitchell D.
    Leeuwenburgh, Christiaan
    [J]. NUTRITION REVIEWS, 2008, 66 (10) : 591 - 596
  • [4] Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age
    Kollman, C
    Howe, CWS
    Anasetti, C
    Antin, JH
    Davies, SM
    Filipovich, AH
    Hegland, J
    Kamani, N
    Kernan, NA
    King, R
    Ratanatharathorn, V
    Weisdorf, D
    Confer, DL
    [J]. BLOOD, 2001, 98 (07) : 2043 - 2051
  • [5] Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice
    Labrie, JE
    Sah, AP
    Allman, DM
    Cancro, MP
    Gerstein, RM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (04) : 411 - 423
  • [6] Steinmann G G, 1986, Curr Top Pathol, V75, P43