Acute psychological stress raises plasma ghrelin in the rat

被引：143

作者：

Kristenssson, Elin

Sundqvist, Monika

Astin, Maria

Kjerling, Marita

Mattsson, Hillevi

de la Cour, Charlotta Dornonville

Hakanson, Rolf

Lindstrom, Erik

机构：

[1] AstraZeneca R&D, GI Biol, S-43161 Molndal, Sweden

[2] Lund Univ, Dept Expt Med Sci, Lund, Sweden

来源：

REGULATORY PEPTIDES | 2006年 / 134卷 / 2-3期

关键词：

A-like cells; ghrelin; stress;

D O I：

10.1016/j.regpep.2006.02.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ghrelin is produced by the A-like cells of the stomach and mobilized by food deprivation. It was reported recently that acute psychological stress increases ghrelin gene expression in rat oxyntic mucosa. The aim of this study was to examine the effect of such stress on circulating ghrelin levels. To this end, we measured plasma ghrelin in Wistar Kyoto (WKY) rats (a high-anxiety strain) and Sprague-Dawley (SPD) rats (a lowanxiety strain), exposed to water avoidance stress for 60 min. Blood was collected before and after the stress. Acute stress increased the plasma ACTH concentration similar to 5-fold (p < 0.01) in both strains of rats, while plasma ghrelin increased by 85% (p < 0.01) in the SPD rats and by 40% (p < 0.001) in the WKY rats. Ghrelin levels after acute stress were higher (p < 0.05) in the SPD rats than in the WKY rats. Sham stress did not affect plasma ghrelin. We conclude that acute psychological stress mobilizes ghrelin and that the SPD rats respond with a higher plasma ghrelin concentration than the WKY rats. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：114 / 117

页数：4

共 35 条

[1] Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans [J].

Ariyasu, H ;

Takaya, K ;

Tagami, T ;

Ogawa, Y ;

Hosoda, K ;

Akamizu, T ;

Suda, M ;

Koh, T ;

Natsui, K ;

Toyooka, S ;

Shirakami, G ;

Usui, T ;

Shimatsu, A ;

Doi, K ;

Hosoda, H ;

Kojima, M ;

Kangawa, K ;

Nakao, K .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (10) :4753-4758

[2] Ghrelin administration affects circulating pituitary and gastro-entero-pancreatic hormones in acromegaly [J].

Arosio, M ;

Ronchi, CL ;

Gebbia, C ;

Pizzinelli, S ;

Conte, D ;

Cappiello, V ;

Epaminonda, P ;

Cesana, BM ;

Beck-Peccoz, P ;

Peracchi, M .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2004, 150 (01) :27-32

[3] Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: Comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone [J].

Arvat, E ;

Maccario, M ;

Di Vito, L ;

Broglio, F ;

Benso, A ;

Gottero, C ;

Papotti, M ;

Muccioli, G ;

Dieguez, C ;

Casanueva, FF ;

Deghenghi, R ;

Camanni, F ;

Ghigo, E .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (03) :1169-1174

[4] Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin [J].

Asakawa, A ;

Inui, A ;

Kaga, T ;

Yuzuriha, H ;

Nagata, T ;

Ueno, N ;

Makino, S ;

Fujimiya, M ;

Niijima, A ;

Fujino, MA ;

Kasuga, M .

GASTROENTEROLOGY, 2001, 120 (02) :337-345

[5] A role of ghrelin in neuroendocrine and behavioral responses to stress in mice [J].

Asakawa, A ;

Inui, A ;

Kaga, T ;

Yuzuriha, H ;

Nagata, T ;

Fujimiya, M ;

Katsuura, G ;

Makino, S ;

Fujino, MA ;

Kasuga, M .

NEUROENDOCRINOLOGY, 2001, 74 (03) :143-147

[6] The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects [J].

Broglio, F ;

Benso, A ;

Castiglioni, C ;

Gottero, C ;

Prodam, F ;

Destefanis, S ;

Gauna, C ;

van der Lely, AJ ;

Deghenghi, R ;

Bo, M ;

Arvat, E ;

Ghigo, E .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (04) :1537-1542

[7] Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage [J].

Brzozowski, T ;

Konturek, PC ;

Konturek, SJ ;

Kwiecien, S ;

Drozdowicz, D ;

Bielanski, W ;

Pajdo, R ;

Ptak, A ;

Nikiforuk, A ;

Pawlik, WW ;

Hahn, EG .

REGULATORY PEPTIDES, 2004, 120 (1-3) :39-51

[8] Expression of ghrelin in the cyclic and pregnant rat ovary [J].

Caminos, JE ;

Tena-Sempere, M ;

Gaytán, F ;

Sanchez-Criado, JE ;

Barreiro, ML ;

Nogueiras, R ;

Casanueva, FF ;

Aguilar, E ;

Diéguez, C .

ENDOCRINOLOGY, 2003, 144 (04) :1594-1602

[9] Ghrelin increases anxiety-like behavior and memory retention in rats [J].

Carlini, VP ;

Monzón, ME ;

Varas, MM ;

Cragnolini, AB ;

Schiöth, HB ;

Scimonelli, TN ;

de Barioglio, SR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 299 (05) :739-743

[10] Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin [J].

Carlini, VP ;

Varas, MM ;

Cragnolini, AB ;

Schiöth, HB ;

Scimonelli, TN ;

de Barioglio, SR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 313 (03) :635-641

← 1 2 3 4 →