ROCKs Are Expressed In Brain Tumors and Are Required for Glioma-Cell Migration On Myelinated Axons

被引：41

作者：

Oellers, Patrick ^{[1
]}

Schroeer, Uwe ^{[1
]}

Senner, Volker ^{[2
]}

Paulus, Werner ^{[2
]}

Thanos, Solon ^{[1
]}

机构：

[1] Univ Eye Hosp Munster, Sch Med, Dept Expt Ophthalmol, D-48149 Munster, Germany

[2] Univ Hosp, Sch Med, Inst Neuropathol, Munster, Germany

来源：

GLIA | 2009年 / 57卷 / 05期

关键词：

glioma; migration; axons; Rho-kinase inhibitor; in vitro; videomicroscopy; RHO-GTPASES; GENE-EXPRESSION; GLIOBLASTOMA CELLS; MALIGNANT GLIOMAS; IN-VITRO; INVASION; ADHESION; BINDING; SYSTEM; KINASE;

D O I：

10.1002/glia.20777

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The interactions between migrating glioma cells and myelinated fiber tracts are poorly understood. We identified that C6 glioma cells can migrate along myelinated chicken retinal axons in a novel coculture, thereby expressing small GTPases of the Rho family and serine/threonine Rho-associated kinases (ROCKs). We found that the ROCK1 isoform is also highly expressed in native human high-grade gliomas. Glioma cells migrated faster in vitro along myelinated axons than on laminin-1, with the former but not the latter being specifically and reversibly blocked by the ROCK inhibitor Y27632. These data suggest that the mechanisms underlying the migration of glioma cells on myelinated axons differ from those underlying the migration on extracellular matrix molecules such as laminin-1. (C) 2008 Wiley-Liss, Inc.

引用

页码：499 / 509

页数：11

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