Acute leukemia and chemotherapy: A modeling viewpoint

被引：37

作者：

Afenya, E

机构：

[1] Department of Mathematics, Elmhurst College, Elmhurst, IL 60126

来源：

MATHEMATICAL BIOSCIENCES | 1996年 / 138卷 / 02期

关键词：

D O I：

10.1016/S0025-5564(96)00086-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A couple of models of acute myeloblastic leukemia (AML) are proposed Normal and leukemic cells are assumed to exist side-by-side with the two cell populations obeying Gompertzian dynamics but with the leukemic cells exercising inhibition over the normal cells. The kinetic equations and steady-state properties of one of the models is analytically obtained. Possible situations of detection or nondetection of malignancy are then discussed. Based on the models of AML, a treatment model is proposed and numerically simulated. Consequently, the option of aggressive treatment of the disease with heavy doses of drugs is shown to be a plausible and worthwhile chemotherapeutic strategy. (C) Elsevier Science Inc., 1996

引用

页码：79 / 100

页数：22

共 31 条

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[2]

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