Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7

被引：76

作者：

Gao Wei ^{[1
]}

Yuan Jie ^{[1
]}

Liu Haibo ^{[2
]}

Wu Chaoneng ^{[1
]}

Huang Dong ^{[1
]}

Zhu Jianbing ^{[1
]}

Guo Junjie ^{[1
]}

Ma Leilei ^{[1
]}

Shi Hongtao ^{[1
]}

Zou Yunzeng ^{[1
]}

Ge Junbo ^{[1
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai, Peoples R China

[2] Tongji Univ, East Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

MICRORNAS; LYMPHOCYTES; CIRCULATION; ACTIVATION; RESPONSES; VESICLES; RECEPTOR; LIGANDS;

D O I：

10.1038/srep42996

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Mature dendritic cells (DCs) home to secondary lymphoid organs through CC chemokine receptor 7 (CCR7). Exosomes derived from DCs (DC-exos) are reported to migrate to spleen and induce inflammation in vivo. In this study, we demonstrated that mature bone marrow DC-exos can activate immature DC and T cells in vitro. Then we intravenously injected DC-exos into C57BL/6 mice, observing that mature DC-exos accumulated more in spleen than immature DC-exos. These DC-exos in spleen could be uptaken by splenetic DCs and T cells and induce an inflammatory response. We further showed that the increased accumulation of mature DC-exos in spleen was regulated by CCR7, whose reduction led to a decrease of accumulation in spleen and attenuated inflammatory response in serum. These data provide us a new perspective to comprehensively understand exosomes, which might inherit some special functions from their parent cells and exert these functions in vivo.

引用

页码：1 / 9

页数：9

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