Cell-biological applications of transfected-cell microarrays

被引：107

作者：

Wu, RZ ^{[1
]}

Bailey, SN ^{[1
]}

Sabatini, DM ^{[1
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0962-8924(02)02354-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell microarrays are a recent addition to the set of tools available for functional genomic studies. Each cell microarray is a slide with thousands of cell clusters that are each transfected with a defined DNA, which directs either the overproduction or the inhibition of a particular gene product. By using a range of detection assays, the phenotypic consequences of perturbing each gene in mammalian cells can be probed in a systematic, high-throughput fashion. Combining well-established methods for cellular investigation with the miniaturization and multiplexing capabilities of microarrays, cell arrays are a versatile tool that can be useful in many cell-biological applications.

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收藏

页码：485 / 488

页数：4

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