Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells

被引：337

作者：

Wolk, Kerstin ^{[1
]}

Sabat, Robert ^{[1
]}

机构：

[1] Univ Hosp Charite, Interdisciplinary Grp Mol Immunopathol Dermatol, D-10117 Berlin, Germany

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2006年 / 17卷 / 05期

关键词：

IL-10; family; IL-22 binding protein; CRF2; cytokines; cytokine receptors;

D O I：

10.1016/j.cytogfr.2006.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Interleukin (IL)-22, discovered in 2000, is a member of the IL-10 family of cytokines. The major sources of IL-22 are activated T1- and NK-cells. IL-22 acts via a heterodimeric receptor complex consisting of IL-22R1 and IL-10R2. Neither resting nor activated immune cells express IL-22R1 or respond to IL-22. In contrast, tissue cells at outer body barriers, i.e. of the skin, kidney, and the digestive and respiratory systems are targets of this cytokine. IL-22 functions by promoting the anti-microbial defense, protecting against damage, and re-organizing non-immune tissues. Furthermore, IL-22 induces acute phase reactants. These findings indicate that IL-22 represents a novel type of immune mediator that, although produced by immune cells, regulates tissue protection and homeostasis. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：367 / 380

页数：14

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