Targeting Metabolic Scavenging in Pancreatic Cancer

被引：6

作者：

Lyssiotis, Costas A. ^{[1
]}

Cantley, Lewis C. ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA

来源：

CLINICAL CANCER RESEARCH | 2014年 / 20卷 / 01期

关键词：

RAS-TRANSFORMED CELLS; AUTOPHAGY; GROWTH; INHIBITION; PATHWAY;

D O I：

10.1158/1078-0432.CCR-13-2570

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth. (C) 2013 AACR.

引用

页码：6 / 8

页数：3

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