Free Brownian motion of individual lipid molecules in biomembranes

被引：159

作者：

Sonnleitner, A ^{[1
]}

Schütz, GJ ^{[1
]}

Schmidt, T ^{[1
]}

机构：

[1] Univ Linz, Inst Biophys, A-4040 Linz, Austria

来源：

BIOPHYSICAL JOURNAL | 1999年 / 77卷 / 05期

关键词：

D O I：

10.1016/S0006-3495(99)77097-9

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The mobility of phospolipids in free-standing and supported membranes was investigated on the level of individual molecules. For the analysis of trajectories a new statistical treatment was developed that permitted us to clearly distinguish different types of diffusional motion. A freely diffusing subfraction of lipids within supported membranes was identified. Its mobility was characterized by a mean lateral diffusion constant of D-supp = 4.6 mu m(2)/s. In comparison, the mobility of lipids embedded in "free-standing" planar membranes yielded an increase in the mean diffusion constant by a factor of 4.5, D-free = 20.6 mu m(2)/s. This increase is attributed to the ultrathin (less than or equal to 1 nm) lubricating water layer between membranes and glass support.

引用

页码：2638 / 2642

页数：5

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