Decompensated cirrhosis and microbiome interpretation

被引:101
作者
Bajaj, Jasmohan S. [1 ,2 ]
Betrapally, Naga S. [3 ]
Gillevet, Patrick M. [3 ]
机构
[1] Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23249 USA
[2] McGuire VA Med Ctr, Richmond, VA 23249 USA
[3] George Mason Univ, Microbiome Anal Ctr, Manassas, VA 20110 USA
关键词
HUMAN GUT MICROBIOME; SYSTEMS BIOLOGY ANALYSIS; HEPATIC-ENCEPHALOPATHY; LIVER-CIRRHOSIS; COGNITION;
D O I
10.1038/nature14851
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
引用
收藏
页码:E1 / E2
页数:2
相关论文
共 15 条
[1]
Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function [J].
Bajaj, Jasmohan S. ;
Cox, I. Jane ;
Betrapally, Naga S. ;
Heuman, Douglas M. ;
Schubert, Mitchell L. ;
Ratneswaran, Maiyuran ;
Hylemon, Phillip B. ;
White, Melanie B. ;
Daita, Kalyani ;
Noble, Nicole A. ;
Sikaroodi, Masoumeh ;
Williams, Roger ;
Crossey, Mary M. E. ;
Taylor-Robinson, Simon D. ;
Gillevet, Patrick M. .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2014, 307 (10) :G951-G957
[2]
Altered profile of human gut microbiome is associated with cirrhosis and its complications [J].
Bajaj, Jasmohan S. ;
Heuman, Douglas M. ;
Hylemon, Phillip B. ;
Sanyal, Arun J. ;
White, Melanie B. ;
Monteith, Pamela ;
Noble, Nicole A. ;
Unser, Ariel B. ;
Daita, Kalyani ;
Fisher, Andmorgan R. ;
Sikaroodi, Masoumeh ;
Gillevet, Patrick M. .
JOURNAL OF HEPATOLOGY, 2014, 60 (05) :940-947
[3]
Modulation of the Metabiome by Rifaximin in Patients with Cirrhosis and Minimal Hepatic Encephalopathy [J].
Bajaj, Jasmohan S. ;
Heuman, Douglas M. ;
Sanyal, Arun J. ;
Hylemon, Phillip B. ;
Sterling, Richard K. ;
Stravitz, R. Todd ;
Fuchs, Michael ;
Ridlon, Jason M. ;
Daita, Kalyani ;
Monteith, Pamela ;
Noble, Nicole A. ;
White, Melanie B. ;
Fisher, Andmorgan ;
Sikaroodi, Masoumeh ;
Rangwala, Huzefa ;
Gillevet, Patrick M. .
PLOS ONE, 2013, 8 (04)
[4]
Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation [J].
Bajaj, Jasmohan S. ;
Hylemon, Phillip B. ;
Ridlon, Jason M. ;
Heuman, Douglas M. ;
Daita, Kalyani ;
White, Melanie B. ;
Monteith, Pamela ;
Noble, Nicole A. ;
Sikaroodi, Masoumeh ;
Gillevet, Patrick M. .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 303 (06) :G675-G685
[5]
A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy [J].
Bajaj, Jasmohan S. ;
Gillevet, Patrick M. ;
Patel, Neeral R. ;
Ahluwalia, Vishwadeep ;
Ridlon, Jason M. ;
Kettenmann, Birgit ;
Schubert, Christine M. ;
Sikaroodi, Masoumeh ;
Heuman, Douglas M. ;
Crossey, Mary M. E. ;
Bell, Debulon E. ;
Hylemon, Philip B. ;
Fatouros, Panos P. ;
Taylor-Robinson, Simon D. .
METABOLIC BRAIN DISEASE, 2012, 27 (02) :205-215
[6]
Linkage of gut microbiome with cognition in hepatic encephalopathy [J].
Bajaj, Jasmohan S. ;
Ridlon, Jason M. ;
Hylemon, Phillip B. ;
Thacker, Leroy R. ;
Heuman, Douglas M. ;
Smith, Sean ;
Sikaroodi, Masoumeh ;
Gillevet, Patrick M. .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 302 (01) :G168-G175
[7]
Chávez-Tapia NC, 2008, MED SCI MONITOR, V14, pCR468
[8]
Characterization of Fecal Microbial Communities in Patients with Liver Cirrhosis [J].
Chen, Yanfei ;
Yang, Fengling ;
Lu, Haifeng ;
Wang, Baohong ;
Chen, Yunbo ;
Lei, Dajiang ;
Wang, Yuezhu ;
Zhu, Baoli ;
Li, Lanjuan .
HEPATOLOGY, 2011, 54 (02) :562-572
[9]
Diabetes Mellitus Is an Independent Prognostic Factor for Major Liver-Related Outcomes in Patients With Cirrhosis and Chronic Hepatitis C [J].
Elkrief, Laure ;
Chouinard, Pascale ;
Bendersky, Noelle ;
Hajage, David ;
Larroque, Beatrice ;
Babany, Gerard ;
Kutala, Blaise ;
Francoz, Claire ;
Boyer, Nathalie ;
Moreau, Richard ;
Durand, Francois ;
Marcellin, Patrick ;
Rautou, Pierre-Emmanuel ;
Valla, Dominique .
HEPATOLOGY, 2014, 60 (03) :823-831
[10]
Quantitative Assessment of the Human Gut Microbiome Using Multitag Pyrosequencing [J].
Gillevet, Patrick ;
Sikaroodi, Masoumeh ;
Keshavarzian, Ali ;
Mutlu, Ece A. .
CHEMISTRY & BIODIVERSITY, 2010, 7 (05) :1065-1075