The nascent polypeptide-associated complex (NAC) promotes interaction of ribosomes with the mitochondrial surface in vivo

被引：71

作者：

George, R

Walsh, P

Beddoe, T

Lithgow, T ^{[1
]}

机构：

[1] Univ Melbourne, Russell Grimwade Sch Biochem & Mol Biol, Melbourne, Vic 3010, Australia

[2] La Trobe Univ, Dept Biochem, Bundoora, Vic 3083, Australia

来源：

FEBS LETTERS | 2002年 / 516卷 / 1-3期

基金：

澳大利亚研究理事会;

关键词：

ribosome; mitochondrion; protein targeting; nascent chain;

D O I：

10.1016/S0014-5793(02)02528-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nascent polypeptide-associated complex (NAC) is a peripheral component of cytoplasmic ribosomes, and interacts with nascent chains as they leave the ribosome. Yeast mutants lacking NAC translate polypeptides normally, but have fewer ribosomes associated with the mitochondrial surface. The mutants lacking NAC suffer mitochondrial defects and have decreased levels of proteins like fumarase, normally targeted to mitochondria co-translationally. NAC might contribute to a ribosomal environment in which amino-terminal, mitochondrial targeting sequences can effectively adopt their appropriate conformation. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：213 / 216

页数：4

共 39 条

[1]

ADES IZ, 1980, J BIOL CHEM, V255, P9918

[2] Alignment of conduits for the nascent polypeptide chain in the Ribosome-Sec61 complex [J].