Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas

被引：30

作者：

Crosignani, S

White, PD

Linclau, B ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Combinatorial Ctr Excellence, Southampton SO17 1BJ, Hants, England

[2] CN Biosci UK Ltd, Novabiochem, Beeston NG9 2LR, England

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 17期

关键词：

D O I：

10.1021/ol0263705

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave-assisted beta-alkylations of several carboxylic acids have been performed with three different beta-alkylisoureas. All reactions are significantly faster compared to conventionally heated reactions, while retaining high chemoselectivity. The combination of microwave technology with the use of the solid-supported isourea 3 enables the synthetic chemist to obtain the pure methyl esters starting from the corresponding acids in less than an hour.

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页码：2961 / 2963

页数：3

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