The pathobiology of eosinophilic inflammation

被引：23

作者：

Boyce, JA ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA

来源：

ALLERGY AND ASTHMA PROCEEDINGS | 1997年 / 18卷 / 05期

关键词：

D O I：

10.2500/108854197778590489

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Eosinophils are bone-marrow-derived granulocytes that are involved in both allergic and nonallergic inflammation. They possess a diverse repertoire of functional responses and effector capabilities, including the release of preformed cytotoxic granule proteins,(1,2) superoxide production,(3) leukotriene biosynthesis,(4) and cytokine production.(5-8) Each of these functional capabilities is linked to the production of tissue damage and physiologic derangements that are characteristic of human diseases associated with eosinophil-dominated inflammation, such as asthma.(9) This review concerns the biology of eosinophils as it pertains to the pathogenesis of allergic disease.

引用

页码：293 / 300

页数：8

共 139 条

[1]

ACKERMAN SJ, 1983, J IMMUNOL, V131, P2977

[2] FORMATION OF CHARCOT-LEYDEN CRYSTALS BY HUMAN BASOPHILS [J].