Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice

被引：59

作者：

Fan, Jun ^{[1
,2
]}

Meng, Qingyan ^{[1
]}

Guo, Guanghua ^{[2
]}

Xie, Yong ^{[2
]}

Xiu, Yiping ^{[1
]}

Li, Tairan ^{[1
]}

Feng, Wei ^{[1
]}

Ma, Liang ^{[1
]}

机构：

[1] Northern Hosp, Dept Burns, Shenyang, Liaoning, Peoples R China

[2] Nanchung Univ, Coll Med, Nanchang, Jiangxi, Peoples R China

来源：

NUTRITION | 2009年 / 25卷 / 02期

关键词：

Glutamine; Enteral nutrition; Peyer's patches; Immunoglobulin A; Burns; PEYERS-PATCHES; LYMPHOCYTE APOPTOSIS; MUSCLE GLUTAMINE; GUT; COMBINATION; GLUTATHIONE; SURVIVAL; TRAUMA; INJURY; TRACT;

D O I：

10.1016/j.nut.2008.08.009

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Objective: The aim of this study was to investigate the effects of enteral nutrition (EN) supplemented with glutamine (GLN) on Peyer's patches and intestinal immunoglobulin A (IgA) response in burned mice. Methods: Thirty-four mice were randomly assigned to a normal control group (n = 40), an EN group (n = 12), and an EN supplemented with GLN (EN + GLN) group (n = 12) and mice in the EN and EN + GLN groups received a 20% total body surface area, full-thickness scald burn on the back. Then the burned mice were fed with conventional EN or EN + GLN for 7 d. There was isonitrogenous and isocaloric intake in the EN and EN + GLN groups. On day 7 after injury, entire intestines were collected and intestinal IgA levels, total lymphocyte yield, lymphocyte subpopulations, and total apoptotic ratio in Peyer's patches were analyzed. Results: Total lymphocyte yield, numbers of lymphocyte subpopulations, and intestinal IgA levels in the EN + GLN group were significantly higher than those in the EN group (P < 0.05). The total apoptotic ratio in Peyer's patches was markedly decreased in the EN + GLN group compared with that in the EN group (P < 0.05). Conclusion: The results indicated that EN supplemented with GLN is superior to conventional EN with respect to improvement of intestinal immunity in burned mice. (C) 2009 Published by Elsevier Inc.

引用

页码：233 / 239

页数：7

共 33 条

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