The Bayesian analysis of a pivotal pharmacokinetic study

被引：5

作者：

Rahman, NJ

Wakefield, JC ^{[1
]}

Stephens, DA

Falcoz, C

机构：

[1] St Marys, Imperial Coll Med, Dept Epidemiol & Publ Hlth, London W2 1PG, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Math, London, England

[3] Glaxo Wellcome, Dept Clin Pharmacokinet, Uxbridge, Middx, England

来源：

STATISTICAL METHODS IN MEDICAL RESEARCH | 1999年 / 8卷 / 03期

关键词：

D O I：

10.1191/096228099667624527

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

The aim of this paper is to carry out a detailed Bayesian population pharmacokinetic analysis of a three-period cross-over study of the drug fluticasone propionate carried out in 12 healthy male volunteers. The study was carried out to characterize the pharmacokinetics of the drug, in particular to investigate dose proportionality. We examine the appropriateness of modelling assumptions via a variety of diagnostic techniques. We also examine the effect of deleting time points at which the concentration was recorded as below the limit of quantification, as opposed to including these points as censored observations. We assess dose proportionality before carrying out a final combined analysis of data from all three doses.

引用

页码：195 / 216

页数：22

共 18 条

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[2]

[Anonymous], 1996, MARKOV CHAIN MONTE C

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