Norovirus in a Dutch tertiary care hospital (2002-2007): frequent nosocomial transmission and dominance of Glib strains in young children

被引:35
作者
Beersma, M. F. C. [1 ]
Schutten, M. [1 ]
Vennema, H. [2 ]
Hartwig, N. G. [3 ]
Mes, T. H. M. [1 ]
Osterhaus, A. D. M. E. [1 ]
van Doornum, G. J. J. [1 ]
Koopmans, M. [1 ,2 ]
机构
[1] Erasmus MC, Dept Virol, NL-3015 CE Rotterdam, Netherlands
[2] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, NL-3720 BA Bilthoven, Netherlands
[3] Erasmus MC, Dept Pediat, NL-3015 CE Rotterdam, Netherlands
关键词
Genotype; Epidemiology; Norovirus; Nosocomial; Rotavirus; ACUTE GASTROENTERITIS; MOLECULAR EPIDEMIOLOGY; VIRAL GASTROENTERITIS; OUTBREAKS; INFECTIONS; PREVALENCE; NETHERLANDS; ENGLAND; SWEDEN; COHORT;
D O I
10.1016/j.jhin.2008.11.018
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We report a retrospective analysis of norovirus (NoV) infections occurring in patients of a tertiary care hospital during five winter seasons (2002/03 to 2006/07). Data were compared with national surveillance data and with corresponding data for rotavirus. Between July 2002 and June 2007, faecal. specimens from 221 (9.0%) of 2458 hospital patients with diarrhoea tested positive for NoV. The incidence in children varied from 2.52 per 1000 admissions in 2004/05 (when testing began to be performed routinely) to 11.9 per 1000 admissions in 2006/07, white the incidence in adults remained stable (mean: 1.49 per 1000 admissions). Two genotypes predominated during the study period: Glib strains occurred mainly in children below the age of two-and-a-half years [odds ratio (OR): 14.7; P < 0.0001] whereas GII.4 strains affected all age groups. Compared with rotavirus infections, NoV infections in children were more often hospital-acquired (59% vs 39%, OR: 2.29; P < 0.01). Among these cases we identified 22 clusters of NoV infection among inpatients. Twelve of 53 patients from whom follow-up samples were available demonstrated tong-term virus shedding. We report a dynamic pattern of sporadic NoV infections in large hospitals, with frequent nosocomial, transmission and with the predominance of GIIb-related strains in children. Effective prevention strategies are required to reduce the impact of sporadic NoV infection in vulnerable patients. (C) 2008 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
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页码:199 / 205
页数:7
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