Glycogen synthase kinase 3: a drug target for CNS therapies

被引：428

作者：

Bhat, RV

Haeberlein, SLB

Avila, J

机构：

[1] AstraZeneca R&D, S-15185 Sodertalje, Sweden

[2] Univ Autonoma Madrid, Ctr Biol Mol, E-28049 Madrid, Spain

来源：

JOURNAL OF NEUROCHEMISTRY | 2004年 / 89卷 / 06期

关键词：

Alzheimer's disease; bipolar disorder; phosphorylation; schizophrenia; signal transduction; Tau kinase;

D O I：

10.1111/j.1471-4159.2004.02422.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the CNS. The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's disease (AD) where abnormal increases in GSK3 levels and activity have been associated with neuronal death, paired helical filament tau formation and neurite retraction as well as a decline in cognitive performance. Abnormal activity of GSK3 is also implicated in stroke. Lithium, a widely used drug for affective disorders, inhibits GSK3 at therapeutically relevant concentrations. Thus while the rationale remains testable, pharmaceutical companies are investing in finding a selective inhibitor of GSK3. In the present review, we summarize the properties of GSK3, and discuss the potential for such a therapy in AD, and other CNS disorders.

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收藏

页码：1313 / 1317

页数：5

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