In situ hybridization detection of human herpesvirus 6 in brain tissue from fatal encephalitis

被引：24

作者：

Ahtiluoto, S

Mannonen, L

Paetau, A

Vaheri, A

Koskiniemi, M

Rautiainen, P

Muttilainen, M

机构：

[1] Univ Helsinki, Haartman Inst, Dept Virol, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Haartman Inst, Dept Pathol, FIN-00014 Helsinki, Finland

[3] Univ Helsinki, Hosp Children & Adolescents, FIN-00290 Helsinki, Finland

[4] Jorvi Hosp, SF-02740 Espoo, Finland

来源：

PEDIATRICS | 2000年 / 105卷 / 02期

关键词：

human herpesvirus 6; in situ hybridization; encephalitis; roseola infantum;

D O I：

10.1542/peds.105.2.431

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase chain reaction for HHV-6 of serum and paraffin-embedded pontine tissue was positive, and serology indicated an acute primary infection. This is the first case showing HHV-6 DNA in the brain cells of an immunocompetent patient with acute encephalitis.

引用

页码：431 / 433

页数：5

共 18 条

[1] FATAL ENCEPHALITIS ENCEPHALOPATHY IN PRIMARY HUMAN HERPESVIRUS-6 INFECTION [J].